Final Review Flashcards
(50 cards)
- Human papilloma virus infection (HPV) is pathogenetically associated with:
(A) Melanoma
(B) Bronchogenic carcinoma
(C) Carcinoma of cervix and esophageal cancer
(D) Carcinoma of the stomach
(E) Mesothelioma
(C) Carcinoma of cervix and esophageal cancer
- HPV types 16 and 18
- Mesothelioma - associated with asbestos
- An 18 yo presents with a well-circumscribed 2-cm mass in her right breast. The mass is painless and has a
rubbery consistency and discrete borders. It appears to move freely through the breast tissue. What is the likeliest diagnosis?
(A) Carcinoma
(B) Cyst
(C) Fibroadenoma
(D) Cystosarcoma phyllodes
(E) Intramammary lymph node
(C) Fibroadenoma
- Most common benign breast tumor in young women
- Fibroadenomas are common, benign, mobile, well-circumscribed, and rubbery
- Cyst are typically not rubbery or mobile
- Carcinomas are harder, fixed and maybe painful
- Which of the following factors has NOT shown to increase a woman’s risk for breast cancer?
(A) Human papilloma virus infection (HPV)
(B) Previous history of benign breast biopsies
(C) Atypia seen on pathology from previous breast cancer
(D) First-degree relative with history of breast cancer
(E) Increasing age
(A) Human papilloma virus infection (HPV)
- Which of the following statements regarding lung cancer is NOT true?
(A) Lung cancer is the most common cause of cancer-related death in both women and man.
(B) Small-cell lung cancer has a relatively good prognosis compared to non-small-cell lung cancer
(C) Bronchogenic carcinoma is seen predominantly in men between the ages of 55 and 60.
(D) Cough is principal presenting symptom.
(E) Hemoptysis is seen in half of all patients
(B) Small-cell lung cancer has a relatively good prognosis compared to non-small-cell lung cancer
- Small cell lung cancer spreads rapidly and has poor prognosis
- Postoperative chemotherapy for colon cancer is recommended for patients with:
(A) Dukes’E
(B) Dukes’A
(C) Dukes’B
(D) Dukes’C
(E) Dukes’D
(D) Dukes’C
- Dukes’ A: Early, local—surgery is enough.
- Dukes’ B: May need chemo if high-risk features.
- Dukes’ C involves lymph nodes, needs adjuvant chemo.
- Dukes’ D: Advanced/metastatic, palliative chemo used
- A patient presents with a pigmented nevus. You perform an excisional biopsy and send it for microscopic
analysis. You would expect an almost 95% cure rate with simple excision alone if the Breslow level was:
(A) < 1mm
(B) > 2,1mm
(C) > 2,5mm
(D) < 2,7mm
(E) > 4mm
(A) < 1mm
- increasing depth = worse prognosis
- <1mm - high survival and cure with excision
- A 45 yo woman presents with bloody nipple discharge. The most likely cause of this problem is:
(A) Fibrocystic breast disease
(B) Intraductal papilloma
(C) Pituitary tumor
(D) Invasive ductal carcinoma
(E) Lobular carcinoma
(B) Intraductal papilloma
- A 65 yo man presents with squamous cell carcinoma of the anus. He is in good health other wise. Metastatic
workup is negative. The treatment of choice for this cancer is:
(A) Radiotherapy
(B) Chemotherapy
(C) A&B
(D) Abdomino-perineal resection
(E) Wide local excision
(C) A&B
- Nigro protocol (chemoradiotherapy) - standard
- Risk factors of melanoma include all of the following EXCEPT:
(A) Exposure to sunlight
(B) Family history of melanoma
(C) Exposure to asbestos
(D) Spitz nevi
(E) Xeroderma pigmentosum
(C) Exposure to asbestos
- The sentinel lymph node (SNB) biopsy has rapidly become a standard procedure for patients with:
(A) Ovarian cancer
(B) Gastric and esophageal cancer
(C) Melanoma and breast cancer
(D) Lung cancer
(E) Colon cancer
(C) Melanoma and breast cancer
- The characteristic features of a malignant tumor include the following EXCEPT:
(A) Typically non-encapsulated
(B) Pleomorphism correlates with the degree of maligancy
(C) Often encapsulated
(D) Histologically, malignant cells and their nuclei often vary widely in shape and size from the cells of origin
tissue
(E) Poorly defined, irregular outline due to local tissue invasion
(C) Often encapsulated
- Bronchogenic carcinoma:
(A) May be a largely preventable disease
(B) Has a 50% cure rate
(C) Responds to tamoxifen
(D) Is synonymous with “coin” lesion
(E) Responds well to X-rays
(A) May be a largely preventable disease
- strong link to smoking - prevention possible
- prognosis is poor
- The marker used in the diagnosis and management of colorectal cancer is:
(A) PSA
(B) CA 15.3
(C) CA 19.9
(D) CEA and AFP
(E) BRCA 1 and BRCA
(D) CEA and AFP
- PSA: Prostate cancer
- CA 15.3: Breast cancer
- CA 19.9: Pancreatic/gastrointestinal
- CEA is the main marker for colorectal cancer; AFP may also be elevated in some GI tumors
- BRCA1/BRCA2: Breast and ovarian cancer.
- Risk factors of esophageal squamous cell carcinoma include all of the following EXCEPT:
(A) Alcohol and tobacco use
(B) Exposure to sunrays
(C) HPV (Human papillomavirus - subtypes 16,18)
(D) Pickled vegetables, smoked meats and fish
(E) Hot liquids
(B) Exposure to sunrays
- HPV 16 and 18
- hot drinks = mucosal injury
- A middle-aged male developes unusual appearing mole on his upper back. He says that his wife has noted a
recent change in its color and shape. The lesion measures 0.7 cm and has ill-delined margins and irregular
pigmentation. The patient is otherwise healthy and takes no medication. Which of the following is the most
appropriate next step in management?
(A) Follow—up examination in 6 months
(B) Cryotherapy witl1 liquid nitrogen
(C) Shave biopsy
(D) Incisional biopsy
(E) Excisional biopsy
(E) Excisional biopsy
- excisional biopsy - gold standard, allows assessment of depth
- A 40 yo woman consults a physician about a “mole” on her neck. The lesion is 2 cm in diameter and slightly irregular, and has a variegated dark red to brown to black color. Wide excision of the lesion demonstrates a malignant neoplasm that extends to a depth of 3 mm. This tumor would be most likely to stain for which of the following tumor markers?
(A) Alpha-fetoprotein
(B) CA—125
(C) Leukocyte common antigen (LCA)
(D) Prostate specific antigen (PSA)
(E) S-100
(E) S-100
- S-100 = classic immunohistochemsitry marker for melanoma
- CA -125 - ovarian cancer marker
- LCA - lymphoma marker
- Which of the following is not typical symptom of late-stage colorectal cancer:
(A) Anemia
(B) Change in bowel habits
(C) Blood in stool
(D) Weight loss
(E) Cardiac arrhythmias
(E) Cardiac arrhythmias
- The characteristic features of radiotherapy include the following EXCEPT:
(A) Primary cure for tumours technically difficult to remove (head, neck, larynx)
(B) Adjuvant radiotherapy- is applied to local tissues and regional lymph nodes after (or occasionally before)
surgery to eliminate micrometastases
(C) Neoadjuvant radiotherapy- short time before surgery, enhances the cure rate for surgery or down-stages a
cancer to make surgery possible
(D) Brachytherapy - local application of radioisotopes
(E) Widely used for renal cell carcinoma
(E) Widely used for renal cell carcinoma
- RCC - radioresistant, surgery is preferred
- According to American Cancer Society (ACS) Guidelines, the optimal age to start colorectal cancer
screening test is:
(A) 25
(B) 35
(C) 60
(D) 50
(E) 40
(D) 50
- A, B and E - too early unless high risk patient (FAP, IBD)
- 60 - too late = delayed detection reduces outcomes
- Nowadays leading cause of cancer death worldwide is:
(A) Ovarian cancer
(B) Gastric cancer
(C) Prostate cancer
(D) Lung cancer
(E) Breast cancer
(D) Lung cancer
- Epidemiologic features associated with increased risk of developing breast cancer include all the following
EXCEPT:
(A) Nulliparous state
(B) First pregnancy occurring late in reproductive life
(C) High fat diet
(D) Trauma
(E) Family history of breast cancer
(D) Trauma
- Nulliparity - increased exposure to estrogen
- Late first pregnancy also has longer exposure to hormones
- Recommendations for early cancer detection include all of the following EXCEPT:
(A) Regular visits to the general practitioner
(B) Patient education
(C) PET (Positron Emission Tomography)
(D) Regular oncological consultation (in higher risk group)
(E) Screening programs
(C) PET (Positron Emission Tomography)
- PET = diagnostic tool, not for general population screening
- reserved for staging/monitoring
- Courvoisier’s sign is referred to:
(A) Obstruction of the duct of Wirsung by carcinoma of the pancreas leading to gall bladder enlargement.
(B) Obstruction of the common bile duct by carcinoma of the pancreas leading to gall bladder enlargement.
(C) Obstruction of the duct of Santorini by carcinoma of the pancreas leading to gall bladder enlargement
(D) Obstruction of the duodenum by carcinoma of the pancreas leading to gall bladder enlargement.
(E) Obstruction of the hepatic duct by carcinoma of the pancreas leading to gall bladder enlargement.
(B) Obstruction of the common bile duct by carcinoma of the pancreas leading to gall bladder enlargement.
- Courvoisier’s sign is a painless, enlarged gallbladder with jaundice, typically caused by obstruction of the common bile duct, usually by a pancreatic head carcinoma
- A pain at the top of the left shoulder referred from diaphragmatic irritation is:
(A) Kupffer sign.
(B) Kussmaul’s sign.
(C) Allen’s sign.
(D) Kehr’s sign.
(E) Goldflam’s sign.
(D) Kehr’s sign
- due to blood/fluid in peritoneal cavity