Flashcards in Final 5 Deck (48):
What causes DNA fragmentation during apoptosis?
Primary mechanism of destruction is due to the activation of what protease?
How are activation cascades set in motion?
Initiator procaspases activated
WHat do initiator caspase cascades lead to?
Two receptors of extrinsic apoptosis induction
TNF and Fas
What protein do Fas receptors recruit?
Recruitment of three procapases form this complex
What does released cytochrome c bind to?
Wheel-like heptamer that apaf-1 forms
WHat does Apaf-1 bind to and activate?
2 Bcl-2 family members that inhibit apopttosis
Two Bcl-2 family members that promote apoptosis
How many BH domains do anti-apoptotic members of Bcl contain?
How many BH domains do pro-apoptotic members of Bcl contain?
3 pro-apoptotic family members with only 1 BH domain
Bad, Bim, Bid
Form a pore in the OMM
Stays located in the cytosol and translocates to mitochondria in response to apoptotic singal
How do Bcl-2 and Bcl-Xl work to prevent apoptosis?
Bind to bax to prevent oligomerization
How do BH3 only protein work to promote apoptosis?
Inhibits Bcl-2 activity
Proteins that direct caspase inhibitors
Cells that counteract IAPs
Family of transmembrane anchors that mediate cell-cell interactions
Family of transmembrane anchors that mediates Cell-matrix interactions
Connect cytoskelton of a cell to the cytoskeleton of its neighbors or ECM
4 types of anchroing junctions
Adherens junctions, desmosomes, hemidesmosomes, actin-linked cell-matrix adhesion
Main function of cadherins
Cell-cell adhesion medaited by calcium
Connect actin filaments from cell to cell
WHat transmembrane adhesion proteins do adherens junctions use?
Connection between IFs from one cell to another
Connect IFs to basal lamina
What type of transmembrane adhesion proteins do hemidesmosomes use?
Primary intracellular anchor protein of hemidesmosomes
Mediate cell-cell adhesions in bloodstream
Proteins that help organize junctional complexes
FOrms selective permeability barrier across epithelial sheets
COmpletely encircle each cell in an epithelial sheet
Each span the bilayer 4 times and interact iwht one another across cells
Allow small molecules to pass directly from cell to cell
Membrane-spanning channel-forming proteins of gap junctions
How many connexin subunits make up a connexon?
Plant version of gap junctions
Main composition of basal lamina
Fibrous proteins and GAG polysaccharides
What organizes the sheet-like structure of the basal lamina?
What does the gamma chain of laminin interact with?
What do the alpha-chains of laminin interact with?
specialized signaling forms of actin-linked cell matrix adhesion
Signaling protein found at focal adhesion
FAK (focal adhesion kinase)