(A) Objective 2 and 4: Identify each of the structures of the human digestive system on a diagram or model; know their functions. Summarize the functions of the accessory digestive glands of humans and other terrestrial vertebrates. See figure 47-4 and know it. The mouth begins the food processing with incisors for biting, canines for tearing and premolars and molars for grinding; saliva is produced by three pairs of salivary glands to moisten and begin enzymatic digestion of starches. The pharynx and esophagus conduct food to the stomach; when a bolus is swallowed, the epiglottis covers the opening to the airway and peristalsis moves the bolus to the stomach. Food is mechanically and enzymatically digested in the stomach where parietal cells secrete HCl and "intrinsic factor" to absorb vitamin B; chief cells produce pepsinogen which gets changed to pepsin in the presence of the acid and is responsible for initiation of protein digestion. After partial digestion in the stomach the contents are called chyme which moves through the pyloric sphincter to the small intestine where most enzymatic digestion takes place. In the duodenum of the small intestine, bile from the liver and enzymes from the pancreas empty via ducts. The villi and microvilli of the small intestine absorb the digested food. The liver secretes bile where it is stored in the gall bladder and then used to emulsify fats; the liver also converts glucose to glycogen for storage, converts amino acids to fatty acids and urea, stores iron and fat-soluble vitamins, detoxifies alcohol and drugs. The pancreas secretes digestive enzymes: trypsin and chymotrypsin (proteases); lipases to degrade fats; amylase to degrade carbohydrates; ribonucleases and deoxyribonucleases to split RNA and DNA to free nucleotides. The chyme is digested mainly in the duodenum of the small intestine and then moves on to the jejunum where villi and microvilli absorb nutrients; then on to the ileum. From there, it enters the cecum of the large intestine where the appendix is located (on the right) on to the ascending transverse and descending colon to the sigmoid colon, rectum and anus. The large intestine functions mainly to remove water from the chyme.
(A) Objective 3: Trace the pathway of an ingested meal in the human digestive system including the step-by-step digestion of carbohydrate, protein, and lipid. See above for details of the pathway: mouth to pharynx to esophagus to stomach to small intestine to large intestine to anus. Enzymatic digestion of carbohydrates to monosaccharides begins with addition of amylase from saliva. Proteins are digested to amino acids by trypsin, chymotrypsin, pepsin, carboxypeptidase and dipeptidases from the pancreas. Fats are degraded to fatty acids and monoacylglycerols by pancreatic lipases after the fat is emulsified by the bile from the gall bladder.
(B) figure 47-10(b) and know the parts. Villi and microvilli increase surface area greatly to absorb better. Each villus is composed of a single layer of columnar epithelial cells through which the digested nutrients diffuse or are actively transported; then, they are picked up by capillary or lymph vessels. Amino acids and glucose are transported to the liver first via the hepatic portal vein. Lipids combine with bile to form micelles in the intestine which are then absorbed by the epithelial cells lining the microvilli. The micelle releases the fat which gets processed by the smooth endoplasmic reticulum of the epithelial cells to form chylomicrons (little droplets of fat). These diffuse into the lacteal (a lymph vessel of the villus). The lymph vessels enter the blood stream directly.
(C) Objective 6: Trace the fate of glucose, lipids, and amino acids after their absorption, and discuss their roles in the body. Excess monosaccharides are converted to glucose and then into glycogen by the liver; too much carbohydrate leads to glucose conversion into lipids. Lipids in the diet usually occur as triacylglycerols which get digested in the liver via β-oxidation into acetyl coenzyme A (a part of the Krebs cycle or citric acid cycle). These are then transported to cells as ketones. Proteins are degraded to amino acids which are then used for human nutrition by rearranging the amino acids into enzymes needed for metabolism. Excess amino acids are deaminated by liver cells producing ammonia and urea as a by-product and energy.
(B) Vitamins are organic compounds essential for normal metabolism; they are usually needed in small amounts as coenzymes to make metabolic processes work more efficiently. Water-soluble vitamins include the B and C vitamins. Fat-soluble vitamins include A, D, E, and K. Be familiar with Table 45-4. Minerals are inorganic nutrients required by cells. Na, Cl, K, Ca, P, Mg and S are needed in amounts of 100 mg/d. Fe, Cu, I, F, and Se are trace elements required in lower amounts.
(C) Objective 8: Contrast basal metabolic rate (BMR) with total metabolic rate; write the basic energy equation for maintaining body weight, and describe the consequences of altering it in either direction. Metabolism is balanced when energy input equals output. The BMR is the rate of energy required during resting and post-digestive conditions. Thus the total metabolic rate equals the BMR plus the energy needed for other activities. Allow more energy input than is needed for total metabolic rate and one gains weight. Allow less energy input than is needed for total metabolic rate and one loses weight.
Objective 5: Draw and label a diagram of an intestinal villus; explain how its structure is adapted to its function. See
Objective 7: Discuss the roles of vitamins and minerals, and distinguish between water-soluble and fat-soluble vitamins.
Objective 9: In general terms, describe the problem of world food supply relative to world population, and describe the
(B) effects of malnutrition. Malnutrition results primarily from a lack of adequate essential amino acids to result in kwashiorkor. The problem is not the lack of food but the unequal distribution of food. While 250 million Americans are spending millions of dollars each year to lose their inebriation of fat from overindulgence in food, billions of Africans and South Americans and Asians die from malnutrition. If we would each fast one day a week and give the money we saved (about $5) to a relief agency like Red Cross or any number of church sponsored relief agencies, the problem would be solved.
(C) Objective 10: Summarize the challenges encountered in obtaining adequate amounts of amino acids in a vegetarian diet and how a nutritionally balanced vegetarian diet could be planned. Most grains and vegetables do not supply all the amino acids essential for growth and metabolism. The solution is to mix grains and legumes (e.g. rice and beans) not just to eat them at different times. In addition, one must provide plenty of leafy vegetables and fruits for vitamins and minerals. Finally, if one is ovolacto (with eggs or dairy products) then it is much easier to be a vegetarian. The advantage of a vegetarian diet is that it is less costly economically and ecologically than eating meat to get all of ones amino acids.
(A) Objective 1: Relate the principal functions of excretory systems to specific osmoregulatory challenges posed by various environments. Excretory systems help maintain homeostasis. Body fluids (e.g. serum) are collected by excretory systems; selective excretion of wastes (e.g. urea) from metabolism is accomplished without getting rid of critical non-waste materials within the body fluid. In marine environments that are stable, simple organisms simply pass wastes by diffusion and lack specialized structures. In estuaries and freshwater environments, the organisms must get rid of wastes and excess water. Terrestrial organisms must conserve water.
(B) Objective 2: Contrast the advantages and disadvantages of excreting ammonia, uric acid, or urea. The principal metabolic wastes are water, carbon dioxide, and nitrogenous wastes such as ammonia, uric acid, and urea. Ammonia is the result of de-amination of amino acids as an organism gets energy from protein. It is very toxic and must be excreted rapidly unless it can be converted to uric acid or urea. Uric acid forms crystals, is relatively non-toxic and is excreted in a relatively dehydrated form. For egg-laying animals, this is important since development within an egg allows for no excretion. Urea is excreted by amphibians and mammals and is made in the liver; it is highly soluble and requires a high amount of water for storage and excretion.
(B) Objective 3: Compare nephridial organs and Malpighian tubules as osmoregulatory organs. Nephridial organs (protonephridia and metanephridia) are specialized for regulation and excretion. Flatworms, rotifers, lancelets and nemerteans have protonephridia with closed ciliated flame cells that bring fluid in from the body cavity and then passes through a system of tubules and excretory ducts to leave the body through excretory pores. Annelids and mollusks have metanephridia which are open at both ends and have cilia; metanephridia are highly vascularized (lots of capillaries surrounding the tubule) in order to reabsorb water, and glucose; they process coelomic fluid and produce a concentrated waste product. Malpighian tubules are found in insects and spiders and are blind tubes which process hemolymph and dump uric acid into the intestine which reabsorbs water and salts.
(B) Objective 4: Relate the function of the vertebrate kidney to the success of vertebrates in a wide variety of habitats. Most vertebrates live in environments where osmoregulation is critical. Many organisms living in the ocean not only must get rid of wastes but they need to excrete excess salt and sequester water if they ingest seawater or prey with high salt content. Organisms living in freshwater need to excrete excess water and bring salts in. Land animals must conserve water while getting rid of the wastes of metabolism. The kidneys (which all these vertebrates have) have allowed a wide adaptation to a variety of habitats. In an odd sort of way, it’s the kidneys that have allowed vertebrates to adapt to so many niches.
(A) Objective 5: Compare the adaptations that freshwater fishes have evolved to solve their challenges of osmoregulation with those of marine bony fishes, sharks and marine mammals. Freshwater fishes must get rid of excess water. Since their body fluids are more concentrated than their surroundings (they are hypertonic), they must bring in salts from the surrounding water. They do this with gills that transport salt in and they excrete very dilute (watery) urine. Freshwater amphibians have cells in the skin that transport in salts. Marine bony fishes are hypotonic compared to their surroundings. They have cells in their gills which excrete salts and they have very few glomeruli in their kidneys so that they excrete a very concentrated urine thus conserving water within their bodies. Sharks, however, deal with the ocean differently; they concentrate urea in their bodies and are thus hypertonic to the ocean; they have well developed kidneys to secrete a dilute urine since water actually flows into the shark; they also secrete salt through a specialized rectal gland. Marine mammals must produce a very concentrated urine to get rid of all the salt they ingest from the seawater they swallow as they eat their food; the high protein diet of these animals (whales, seals, etc) demands that they get rid of urea as well.
(A) Objective 6: Label on a diagram the organs of the mammalian urinary system, and give the functions of each. Know figure 48-7 and 48-8. The kidney, urinary bladder and their ducts (ureters leading from kidney to bladder and urethra leading from bladder to exit) and the adrenal glands are all part of the urinary system. TOsmoregulation, Wastes Chap. 48
he kidney is composed of an outer cortex and an inner medulla. The medulla is composed of 8-10 "pyramids" of renal papilla where the collecting ducts empty. These then go into the ureters which goes into the bladder.
(B) Objective 7: Identify on a diagram the principal parts of a nephron (including associated blood vessels), and give the functions of each structure. Know figure 48-9 and figure 48-10. The nephron is the functional unit of the kidney; a single kidney contains several million nephrons. Bowman's capsule collects fluid (serum) from the glomerulus (a conglomeration of afferent arterioles). The fluid collected from Bowman's capsule then goes through the renal tubule which consists of the proximal convoluted tubule, loop of Henle, and the distal convoluted tubule which then goes into the collecting duct of the kidney now as urine. All along this renal tubule, water is reabsorbed into the capillaries while the wastes remain within the tubule. The blood that went into the glomerulus (that was surrounded by Bowman's capsule) flows out into the efferent arterioles that branch into a second set of capillaries called the peritubular capillaries which surround the renal tubules and reabsorb non-waste materials to return them to the venous circulation ultimately merging in the renal vein.
(B) Objective 8: Trace a drop of filtrate from Bowman's capsule to its release from the body as urine. Small molecules are forced out of the glomerular capillaries (which are fenestrated - have small pores) into the lumen of Bowman's capsule which also has cells that are permeable (called podocytes and are separated from each other with slit pores). The glomerular capillary walls and podocytes make up the filtration membrane which is impassable to cells in the blood and most proteins. Up to 4.5x the amount of fluid in the entire body is filtered and mostly reabsorbed. The reabsorption process is highly selective with 99% of the filtrate being reabsorbed from the renal tubules. The proximal convoluted tubule is the most important in reabsorption. The cortical nephrons have small glomeruli and short loops of Henle and produce a relatively dilute urine. Juxtamedullary nephrons have large glomeruli and long loops of Henle and produce a concentrated urine. The descending loop of Henle has walls which are permeable to water but impermeable to sodium and urea thus allowing water to come out of the renal tubule and be reabsorbed by the capillaries (called vasa recta). The ascending loop has walls that are just the opposite in permeability and allow salt to come out but not water. Thus the interstitial fluid in the medulla becomes quite salty and pulls even more water out of the descending loop of Henle. The primary role of the loop of Henle, then, is to concentrate the urine even further. This process forms the urine (where the urea is concentrated) which goes to the collecting duct, etc as described in 7 above.
(C) Objective 9: Describe the regulatory effects of ADH, aldosterone, and atrial natriuretic peptide (ANP). Urine volume is regulated by the hormone ADH (anti-diuretic hormone) which is produced by the posterior pituitary and targets the collecting ducts to make them more permeable to water resulting in concentrated urine. Secretion of ADH comes under the control of the hypothalamus which has receptors that are stimulated by osmotic changes in the blood; it also has a thirst receptor that causes increased fluid intake. Aldosterone controls sodium reabsorption. Aldosterone is produced by the adrenal cortex and stimulates the distal convoluted tubules and collecting ducts to increase sodium reabsorption.
Endocrine Regulation Chap 49 (A) Objective 1: Define hormone and endocrine gland and identify sources of hormones other than endocrine glands. Hormones are chemical messengers responsible for the regulation of body processes. Endocrine glands produce hormones and secrete them into the
surrounding tissue; there, they can get absorbed into the capillaries and transported by the blood to target tissues where the hormone has its effect. In addition, some hormones are produced by neuro-endocrine cells (part of the nervous system). There are four types of hormones: steroids synthesized from cholesterol (e.g. testos-terone, estradiol, and ecdysone); amino acid derivatives include amines (e.g. epinephrine and norepinephrine); protein (peptide)-type hormones are short chains (e.g. oxytocin, ADH, growth hormones, and TSH); and fatty acid derivatives likr prostaglandins. (C) Objective 2: Compare mechanisms of action of steroid and protein-type hormones; include the role of second messengers such as cyclic AMP. Some hormones bind to specific receptor proteins in target cells to affect the metabolism of the target cell (protein-type hormones). Some hormones enter the cell and activate genes (e.g. steroids) to produce specific enzymes; it is the enzymes, however, that actually cause the effect that the hormone stimulated. Cyclic AMP works as a second messenger. A primary hormone binds with receptors on the target cells to activate a membrane-bound enzyme such as adenylyl cyclase. The "G protein" is bound to GDP (guanosine diphosphate) when it is inactive. When the hormone binds to a stimulatory receptor it causes the G protein to release GDP and binds to GTP instead. When this happens, adenylyl cyclase is activated which then catalyzes the conversion of ATP to cAMP which activates protein kinase which catalyzes the phosphorylation of a specific protein which triggers a chain of reactions that causes the particular metabolic effect of the hormone. It’s a kind of Rube Goldberg device! (A) Objective 3: Summarize the roles of hormones in invertebrates. Invertebrate hormones regulate growth, development, metabolism, reproduction, molting, and pigmentation and are secreted by neurons (e.g. color changes in crustaceans). In some insects, temperature changes trigger neuroendocrine cells in the brain to release brain hormone (BH) which is transported down axons and stored in the corpora cardiaca; when released, BH stimulates the prothoracic glands to release molting hormone (MH). The MH triggers growth and molting. Endocrine glands also secrete juvenile hormone which suppresses metophorosis during larval growth to prevent the pupa from molting. When juvenile hormone is gone, the pupa can molt and progress on to an adult. (B) Objective 4: Identify the principal vertebrate endocrine glands, locate them in the body and list the hormones secreted by each. See figure 49-12 and table 49-1. (A) Objective 5: Summarize the regulation of endocrine glands by negative feedback mechanisms, and give specific examples. Vertebrate endocrine glands constantly secrete at least a small amount of hormone so that hormones are constantly circulating free or bound to plasma proteins and are constantly being removed from circulation by target tissues (e.g. liver and kidneys). Negative feedback regulates the secretion of most hormones (e.g. thyroid). A high concentration of hormone inhibits further secretion; the effect of a hormone is usually opposite the effects of the stimulus. (B) Objective 6: Justify the description of the hypothalamus as the link between nervous and endocrine systems, and describe the mechanisms by which the hypothalamus exerts its control. The hypothalamus integrates neural and endocrine regulation; it links the nervous and endocrine system. Neurons of the hypothalamus secrete neuro-hormones which target the release of hormones by the pituitary gland which then secretes at least 9 hormones that have a wide variety of target cells and effects on the body. The hypothalamus affects the pituitary gland. (C) Objective 7: Compare the functions of the posterior and anterior lobes of the pituitary; describe the actions of their hormones. The posterior lobe releases two hormones: oxytocin and ADH (peptide hormones). Oxytocin stimulates uterine contractions during labor; it also causes muscle cells in the breast to contract while nursing in order to result in the expulsion of milk (the "letting-down" reflex). The anterior lobes secrete tropic hormones (TSH, ACTH, FSH, and LH). TSH stimulates thyroid to produce thyroid hormones; ACTH stimulates the adrenal cortex to produce adrenal cortical hormones; FSH and LH stimulate gonad function. (C) Objective 8: Describe the actions of growth hormone on growth and metabolism, and contrast the consequences of hyposecretion and hypersecretion. Growth hormone (aka somatotropin) stimulates protein synthesis and thus growth as well as increasing fat and carbohydrate metabolism. Hyposecretion of GH causes dwarfism; hypersecretion causes gigantism or acromegaly. (B) Objective 9: Define the actions of the thyroid hormones, their regulation, and the thyroid disorder discussed in this chapter. Thyroid hormones increase metabolic rate. Thyroid is regulated by negative feedback. When thyroid drops, the pituitary produces TSH which stimulates the thyroid to produce thyroid hormones. Malfunction leads to goiter, sluggish metabolism, and even mental malfunction. Hypothyroidism leads to a condition known as cretinism (retarded physical growth) while hyperthyroidism leads to chronically feeling hungry or craving for something. (B) Objective 10: Contrast the actions of insulin and glucagon, and describe the disorders associated with the malfunction of the islets of the pancreas. Insulin lowers the concentration of glucose in the blood while glucagon raises the concentration of glucose in the blood. Malfunctions result in diabetes or hypoglycemia. (B) Objective 11: Describe the actions of the adrenal glands, including their role in helping the body adapt to stress. The adrenal glands are located above the kidney; they initiate an alarm reaction by secreting epinephrine and norepinephrine which control flight or fight reactions.
is common among some animal groups and produces identical offspring from the parent with diversity coming only from mutations. Parthenogenesis can occur in some reptiles, insects, crustaceans and involves development from an unfertilized egg. Sexual reproduction is most common in most animals; it involves fusion of a sperm and an egg. External fertilization involves fusion of sperm and egg outside the body (aquatic organisms). Internal fertilization involves delivery of the sperm into the female body. Hermaphrodites can produce both sperm and egg within the same body.
Reproduction Chap. 50 (not covered) (A) Objective 1: Compare asexual and sexual reproduction and compare external and internal fertilization. Asexual reproduction
(A) Objective 2: Label the structures of the human male reproductive system on a diagram and describe their functions. See figures 50-3, 4, and 8 and read accompanying text.
(B) Objective 3: Trace the passage of sperm cells through the human male reproductive system from their origin in the seminiferous tubules to their expulsion from the body in semen. Spermatogenesis occurs within the testis in the seminiferous tubules where spermatogonia (diploid) divide by mitosis to form more. These undergo meiosis to produce four haploid spermatids. The spermatids differentiate into a mature sperm by developing a flagellum, an enzyme cap (acrosome) and by decreasing their cytoplasm. Sperm leave the seminiferous tubules to go into the tubules of the epididymus where they mature and are stored. When they are ejaculated, they go from the epididymus into the vas deferens which leads to the ejaculatory duct that passes through the prostate gland to the urethra and out through the penis. Some of the accessory glands produce the fluid portion of the semen: seminal vescicles secrete a fluid rich in fructose (for energy) and prostaglandins (to neutralize the acids in the vagina). The bulbourethral glans produce a mucous secretion to lubricate the penis to facilitate penetration.
(A) Objective 4: Describe the actions of testosterone and of the the gonadotropic hormones in the male. The hypothalamus secretes gonadotropin-releasing hormone which stimulates the anterior pituitary to secrete FSH and LH. FSH stimulates development of the seminiferous tubules; LH stimulates the interstitial cells to secrete testosterone. Inhibin (secreted by Sertoli cells) inhibits FSH production. Testosterone stimulates spermatogensis, growth, and development of the male primary and secondary sexual characteristics.
(A) Objective 5: Label the structures of the human female reproductive system on a diagram and describe their functions. See figures 50-10, 11, 12 and 14 and read accompanying text.
(B) Objective 6: Trace the development of an ovum and its passage through the female reproductive system until it is fertilized. Oogenesis occurs in the ovaries and begins with the development of the oogonia which become primary oocytes during prenatal development. Each primary oocyte and the cells surrounding it form a follicle. Each month, a primary oocyte completes its first meiotic development forming a first polar body and the secondary oocyte. The first polar body may go on to divide again to form two more polar bodies that ultimately disintegrate. Meanwhile, the secondary oocyte (which remains in meiosis stage II until fertilization) is ejected from the follicle during ovulation with the remaining follicular cells forming the corpus luteum. If a sperm cell penetrates the oocyte, the oocyte finishes meiosis to form one haploid ovum and a polar body prior to becoming diploid with the addition of the sperm cell’s chromosomes. The ovum, once fertilized, becomes a zygote that implants into the uterine wall to become an embryo.
(B) Objective 7: Identify the important events of the menstrual cycle, such as ovulation and menstruation; explain the actions of each of the hormones involved; describe the hormonal regulation of the menstrual cycle. Gonadotropin-releasing hormone stimulates the anterior pituitary to release FSH and LH. FSH stimulates the development of a new follicle in the ovary. The follicle secretes estrogen that stimulates the development of the endometrium and stimulate production of LH. After ovulation, LH stimulates development of the corpus luteum which produces progesterone and some estrogens. If fertilization does not occur, the corpus luteum disentegrates and stops the production of hormones which brings on menstruation. If fertilization does occur and implantation happens, then human chorionic gonadotropin signals pregnancy.
(A) Objective 8: Summarize the process of human fertilization. Fertilization is the result of the fusion of egg and sperm to produce a zygote. Fertilization can be the result of sexual response in which both males and females respond to sexual desire, excitement, orgasm, and resolution. Although orgasm is not necessary for a fertilization to take place for a woman it is required for a male since ejaculation usually accompanies a male's orgasm.
(C) Objective 9: Compare the modes of action, effectiveness, advantages and disadvantages of birth control methods in table 48-3. See table 48-3!
(C) Objective 10: Identify common sexually transmitted diseases, and describe their symptoms, effects, and treatments. See table 48-5!
Development Chap 51 (not covered) (A) Objective 1: Summarize the roles of cell division, cell growth, morphogenesis, and cell differentiation in the development
of an animal. The single-celled zygote undergoes division and then begins to divide over and again to produce an increase in cell numbers (division) and in cell size (growth). Morphogenesis is the process by which cells organize themselves by cell migrations to shape the animal into the intricate pattern of tissues and organs. But they must also become specialized by cell differentiation by biochemically and structurally becoming different to perform specific tasks for the development of the whole animal. (B) diploid number of chromosomes when the sperm and ovum come together. The first step in fertilization is contact and recognition where calcium release allows the acrosome to release proteolytic enzymes that digest a path through the jelly coat; bindin causes the acrosome of the sperm to adhere to the vitelline membrane of the egg in a species specific fashion. As the sperm enters the egg, an electrical change in the egg plasma membrane occurs to prevent additional sperm from entering; the slow block to polyspermy (cortical reaction) involves depolarization of the egg plasma membrane due to calcium release which also is involved in depolarization that causes a chemical change in the vitelline membrane to form a block (fast block to polyspermy). Then the egg and sperm nuclei fuse due to microtubules propelling the sperm nucleus toward the egg nucleus. Finally the egg is activated and development begins: protein synthesis is triggered and cytoplasm separates into specific areas for the further development of the embryo. (A) Objective 3: Trace the early development of the embryo from zygote through cleavage; formation of the morula, blastula, and gastrula; and early organ development. As the zygote divides, the ovum contributes the majority of the zygote cytoplasm despite both sperm and egg contributing the same number of chromosomes. Cleavage is a series of rapid mitotic divisions without cell growth until it reaches a 32 cell ball of cells called a morula. Divisions continue to form the hollow blastula with cavity called the blastocyst or blastocoel. Cells continue moving and migrating around by ameboid motion to form the gastrula from which the three germ layers are derived. (A) Objective 4 & 5: Contrast early development, including cleavage and gastrulation, in the sea star (or in amphioxus), the amphibian, and the bird. Summarize the fate of each of the germ layers. Isolethical eggs typically have a uniform yolk distribution and is typical of invertebrates and simple chordates; cleavage can be radial (deuterostomes) or spiral (protostomes). Telolethical eggs have their yolk concentrated at the vegetal pole (most vertebrates); in birds and some reptiles, the blastodisc splits into the epiblast and hypoblast separated by the blastocoel. The gastrula is a three-layered embryo including endoderm, mesoderm, and ectoderm each with a specific fate. The archenteron is endoderm that develops into the digestive tract and its accessory organs. The outer layer of the gastrula makes up the ectoderm which forms the epidermis, nervous system, and sense organs. The mesoderm develops between ectoderm and endoderm to give rise to skeletal, muscular, circulatory, excretory, and reproductive tissues. (B) development of the nervous system and is the first organ system to develop in vertebrates. The notochord grows and induces the overlying ectoderm to form a neural plate which folds in to form the neural groove and the surrounding neural folds which fuse to form a hollow neural tube where the anterior portion forms the brain and the rest forms the spinal cord. The neural crest forms on either side of the point of fusion and cells migrate to form the dorsal root ganglia, the postganglionic sympathetic neurons, many sense organs and all pigment forming cells. The trachea grows from the gut and the lungs develop from it. The pharyngeal pouches grow laterally from the pharynx. The branchial grooves meet the pharyngeal pouches and form the gill slits and gills in aquatic vertebrates. The heart/circulatory organs form from mesoderm. (B) membrane. Extraembryonic membranes protect and nourish the embryo. Terrestrial vertebrates have four extraembryonic membranes that develop from the germ layers but are not really part of the embryo since they are lost at birth. The chorion and amnion enclose the embryo where the amniotic cavity fills with fluid to cushion the embryo. The allantois is an outgrowth of the gut and stores or eliminates nitrogenous wastes in birds and reptiles. In humans, it contributes to the formaiton of the umbilical vessels. The yolk sac encloses the yolk in vertebrates and, in humans, helps in formation of red blood cells.
(C) Objective 8: Describe the general course of human development from fertilization to birth. Gestation is 266 (38 weeks) days from conception. Development begins in the oviduct about 24 h after fertilization when the zygote divides to form a 2-celled embryo. As it enters the uterus after about 5 days it has just lost its zona pellucida and continues to float free for a few more days as a blastocyst. When it finally implants into the uterine wall, its trophoblast forms the chorion and amnion which later form the placenta and amniotic sac. The actual embryo begins to form on the 7th day of development from conception and only if it implants into the uterine wall. Organ development does not begin in the embryo until the 2nd or 3rd week when the nervous system begins to form and the heart begins to beat after 3.5 weeks. Only after 2 months of development does the embryo become a fetus when it is fully recognized as human and the sexes can be differentiated. During the 2nd and 3rd trimesters, the fetus moves freely and the heart can be heard with a stethoscope. If born at 24 weeks (168 days), the fetus has a 50% chance of survival. If born after 37 weeks it is premature; it has a good chance of surviving if born after 30 weeks. During initiation of parturition, the uterus becomes responsive to oxytocin and contracts; the cervix dilates and flattens and the amniotic sac ruptures. The second stage includes delivery of the fetus by a combination of contractions of uterine and abdominal muscles. The third stage includes expulsion of the placenta and fetal membranes.
Objective 2: Summarize the functions of fertilization, and describe the four processes involved. Fertilization restores the
Objective 6: Define organogenesis, and trace the early development of the nervous system. Organogenesis begins with the
Objective 7: Trace the development of the extraembryonic membranes and placenta, giving the functions of each
(C) Objective 9, 10, 11: Contrast postnatal with prenatal life, describing several adaptations that the neonate must make in order to live independently. List steps a pregnant woman can take to promote the well-being of her developing child. Identify the stages of the human life cycle; describe the anatomical and physiological changes that occur with aging, and discuss current hypotheses of aging. The neonate must adapt to its new environment, for example, by the initial breathing response due to the accumulation of carbon dioxide. Prenatal development is severely affected by anything circulating in the maternal blood (see table 49-3) demanding that a woman abstain from many drugs and foods for the health of the child. The human life cycle extends from fertilization to death with aging resulting in decreased functions of the organ systems: hormonal changes, autoimmune responses, accumulation of wastes in the cells, changes of molecular structure of critical macromolecules, even exposure to cosmic radiation and x-radiation have been hypothesized for the fact that despite all our advances in medicine, little significant changes in the average age of humans has been seen. Genetic predisposition for a long life is the best explanation: choose your parents wisely for a long life!
Animal Behavior Chap. 52
"Do you know when the time is right for the mountain goats and deer to give birth? . . . Is it through your wisdom that the hawk flies? . . . Are you the one that commands the eagle to fly and build his nest so high?" God speaking to Job in Job 39. experience. Just because a behavior is innate, however, does not mean it is desirable in a social context. We are told to overcome our natural desires (Rom. 6:19; Rom 8:9-13 & Rom 13:14; Gal 5:16-19 & 24 Gal 6:8; Eph 2:3; Col 3:5; Jude 1:19) and be self-sacrificial in our Christian walk "considering others better than ourselves." (Phil. 2:3). Clearly, God asks us to reject our natural animal heritage of selfish behaviors to serve Him. No longer is the excuse "God made me this way" acceptable! Understanding animal behavior allows one to understand God's creative mind.
(A) Objective 1: Explain why behavior is adaptive, homeostatic, and flexible. Behavioral capacity is inherited and is modified by the environment. Behaviors that permit adaptation to the environment and survival are passed on to their offspring; such behaviors also tend to be homeostatic for the individual as well. Behaviors, even some instinctual ones, can be modified by training and learning and therefore need to be considered flexible.
Studies continue to support that much of even human behavior is genetically pre-determined or innate as well as much being learned by
(A) Objective 2: Cite examples of biological rhythms and the mechanisms responsible for them. Biological rhythms occur oriented around environmental events such as tides, solar cycles and annual patterns. The animal behaviors actually anticipate these environmental changes (e.g. crabs returning to their burrows before high tide); they even occur in the absence of environmental cues that we might think could be training cues. How the crabs "know" that high tide is coming is encoded in the "wisdom" of the years of adaptation to that environment: DNA. This encoding causes the pineal gland and hypothalamus to secrete hormones that stimulate these behaviors in vertebrates. Other biological rhythms include circadian (daily) rhythms, diurnal, nocturnal, and crepuscular rhythms, and lunar.
(B) Objective 3: Summarize the contributions of heredity, environment, and maturation to behavior. The capacity for certain behaviors is inherited but it also is modified by environmental factors depending on the nervous system and endocrine system development of the animal. The behaviors are also modified by learning: birds are born with the rudimentary genetic pattern of their specific mating songs but learn the details from their parents. Some behaviors are entirely innate (instinctual) just as some are entirely learned. One of the funniest innate behaviors (fixed action patterns) to watch is geese retrieving "eggs" that are placed outside of their nest (sign stimuli). One mother goose who had a nest on a golf course was frantic in trying to keep her "eggs" within the nest as the golfers tried making putts on the green where she had her brood. The golf balls resembled the eggs sufficiently to keep her frantically busy!
(B) Objective 4: Classify a learned behavior as an example of classical conditioning, operant conditioning, habituation, or insight learning. Entirely learned behaviors are those influenced by experience alone. One way of learning is by classical conditioning where a reflex becomes associated with a new stimulus (Pavlov's dogs). In operant conditioning, spontaneous behavior is reinforced. Reinforcement may be positive (a behavior is rewarded with a stimulus if performed) or negative (a stimulus is removed if a behavior is performed). Habituation allows an animal to ignore irrelevant stimuli (animals not bothered by the presence of humans). Insight learning involves recalling past learning experiences to solve new problems (primates are particularly good at this).
(B) Objective 5: Discuss adaptive significance of: imprinting, migration, optimal foraging behavior. Imprinting is learning that occurs during a critical period such as a chick recognizing its mother shortly after hatching so that the chick can survive. Migration is triggered by day length and may rely on celestial, magnetic, or olfactory clues. Migration allows for survival of harsh winters and cuts down on competition in a single area. Optimal foraging behavior is a set of hypotheses that describe how animals optimize time and reward in seeking food.
(A) Objective 6: Give a description of an animal society and identify the adaptive advantages of cooperative behavior. Define kin selection (inclusive fitness) and its role in the maintenance of insect and other animal societies. Compare society of a social insect with human society. Social behavior involves interaction between members of the same species to enable the population to survive if its individuals cooperate with each other. Examples include bee and ant colonies, wolf packs, and others. Kin selection can promote altruistic behavior (selfless behavior). Siblings from the same set of parents each have the same set of genes (1/2 from each of the parents) equally shared by each brother or sister. Therefore, if one of the siblings has a child, he is just as related genetically to his own child (1/4 the genes of mom and dad) as he is to his nephew (also 1/4 the genes of mom and dad). One sees this behavior in wolf packs where only an alpha male and female are allowed to breed and the children help rear their parent's offspring since an "identical" set of genes are passed on by a related individual. The classic example of altruistic behavior is seen in bee colonies where the drones are haploid (they develop from unfertilized queen eggs). The female workers develop from the queen's eggs which are fertilized by a select drone and are diploid. Thus the workers are virtually identical to each other. If the female workers were to reproduce by mating with other drones, they would be less related to their own offspring than they are related to each other! Thus, the workers defer reproduction to care for the offspring of the queen. Humans often display altruistic behaviors for their comrades or friends that goes beyond kin selection because cultural elements can often overcome natural tendencies. This is especially well developed (or at least should be) in Christianity where Jesus gives us the ultimate example of how to be altruistic to our "brethren."
(B) Objective 7: Summarize modes of communication that animals use. Communication is needed for social behavior and results in
the modification of behavior by another organism. Communication between animals can be by sound, scent, electrical signals (in fish), pheromones (in insects mainly), dances (bees).
(A) Objectives 8: Discuss adaptive significance of dominance hierarchy, territoriality, home range, courtship behavior, and pair bonds. Dominance hierarchies reduce aggressive behavior. Territoriality is a section of the home range that is defended and tends to reduce aggressive conflicts. Courtship behaviors allow for mate selection based on those behaviors rather than aggression. Pair bonds exist between mates to ensure reproductive success. Pair bonds are most common in bird species (90%) but very few other examples exist. Humans are the only primates that pair bond . . . or at least serially pair bond.