Final Flashcards
(12 cards)
GRADE framework components
Risk of bias, consistency, directness, precision, publication bias
Cochrane risk of bias
selection bias, performance bias, detection bias, attrition bias, reporting bias
Risk of bias
internal validity and important limitations
Consistency
homogenicity vs heterogenicity
Directness
do they directly use the outcome/intervention/population or surrogates
Precision
do the confidence intervals rule out no effect
Publication bias
are there trials not used or published
Selection bias
adequate randomization, adequate allocation concealment, baseline characteristics
Performance bias
blinding
Detection bias
outcome assessors blinded
Attrition bias
attrition high or differential, missing data handled appropriately
Reporting bias
evidence of selective outcome reporting
