Flashcards in Final Breast Deck (65)
what cells line lactiferous ducts and lobules?
luminal epithelial cells
What do luminal epithelial cells do?
What do myoepithelial cells do?
- assist in milk ejection during lactation
- maintain normal structure/function of lobule and basement membrane
What are the top 3 infectious bacteria that enter through cracks and fissures in the nipple?
#1 Staph aureus
#2 Staph epidermitis
#3 Strep epidermitis
Peri-ductal mastitis is associated with what RF?
What is galactorrhea?
appearance of milk in non-pregnant, non-breastfeeding female or in a male.
Mammary duct ectasia is characterized by what histological finding?
Lipid laden macrophages in the lactiferous ducts
- foamy histiocytes also found in fat necrosis
Where are fibrocystic breast changes most commonly found?
Upper outer quadrant (just like malignancy)
Stromal fibrosis and peri-ductal lymph infiltrate indicate what?
lymphocytic mastopathy: WBC surrounded by fibrotic stromal tissue
hist of fibroadenoma
no nuclear atypia
hist of lactating adenoma
hyperplastic lobules with marked cytoplasmic vacuolization
duct cells become flattened and nuclei appear next to luminal surface as flattened, dark staining nuclei, lining up in medial ductal facing surface in what lesions?
What is the most common type of breast CA?
infiltrating ductal carcinoma (80% of all breast CA)
What are characteristics of infiltrating ductal carcinoma?
not movable on exam
what type of breast cancer has signet ring appearance?
What to Paget cells look like?
large, round cels with pale cytoplasm and pleomorphic nuclei seen in epidermis
What cells are affected by Paget cells?
Only nipple cells, the other cells are normal
What are the 3 main types of breast CA?
Ductal (intraductal is the same thing)
Nipple (also called Paget's disease)
What is hist of ductal cells compared to myoepithelial cells?
ductal cells: dark staining and concentric
myoepithelial cells: lighter staining and surround ductal epithelium
What is amastia?
congenital condition where breast tissue, nipple, and areola are absent
What is amazia?
congenital condition where mammary gland tissue is absent, but nipple and areola are present
What is athelia?
presence of glandular tissue with no nipple or areola
Where are supernumerary nipples usually found?
usually along milk line, but rarely can be found beyond mammary line
what are some causes of galactorrhea
medication side effect
underlying malignancy (30% of women > 60yo)
inflammation of parenchyma of mammary gland
etiology of mastitis?
inflammatory or infectious
What are top 3 bacteria that cause infectious mastitis?
#1 staph areus
#2 staph epidermitis
#3 strep epidermitis
during pregnancy or right after
what pt population is more likely to get peri-ductal mastitis?
Smokers (90% of pt are smokers)