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Flashcards in Final Breast Deck (65)
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1

what cells line lactiferous ducts and lobules?

luminal epithelial cells
myoepithelial cells

2

What do luminal epithelial cells do?

produce milk

3

What do myoepithelial cells do?

- assist in milk ejection during lactation
- maintain normal structure/function of lobule and basement membrane

4

What are the top 3 infectious bacteria that enter through cracks and fissures in the nipple?

#1 Staph aureus
#2 Staph epidermitis
#3 Strep epidermitis

5

Peri-ductal mastitis is associated with what RF?

Tobacco smoking

6

What is galactorrhea?

appearance of milk in non-pregnant, non-breastfeeding female or in a male.

7

Mammary duct ectasia is characterized by what histological finding?

Lipid laden macrophages in the lactiferous ducts
- foamy histiocytes also found in fat necrosis

8

Where are fibrocystic breast changes most commonly found?

Upper outer quadrant (just like malignancy)

9

Stromal fibrosis and peri-ductal lymph infiltrate indicate what?

lymphocytic mastopathy: WBC surrounded by fibrotic stromal tissue

10

hist of fibroadenoma

well encapsulated
no nuclear atypia

11

hist of lactating adenoma

hyperplastic lobules with marked cytoplasmic vacuolization

12

duct cells become flattened and nuclei appear next to luminal surface as flattened, dark staining nuclei, lining up in medial ductal facing surface in what lesions?

intraductal papilloma

13

What is the most common type of breast CA?

infiltrating ductal carcinoma (80% of all breast CA)

14

What are characteristics of infiltrating ductal carcinoma?

not movable on exam
irregular borders
hard

15

what type of breast cancer has signet ring appearance?

lobular carcinoma

16

What to Paget cells look like?

large, round cels with pale cytoplasm and pleomorphic nuclei seen in epidermis

17

What cells are affected by Paget cells?

Only nipple cells, the other cells are normal

18

What are the 3 main types of breast CA?

Ductal (intraductal is the same thing)
Lobular
Nipple (also called Paget's disease)

19

What is hist of ductal cells compared to myoepithelial cells?

ductal cells: dark staining and concentric
myoepithelial cells: lighter staining and surround ductal epithelium

20

What is amastia?

congenital condition where breast tissue, nipple, and areola are absent

21

What is amazia?

congenital condition where mammary gland tissue is absent, but nipple and areola are present

22

What is athelia?

presence of glandular tissue with no nipple or areola

23

Where are supernumerary nipples usually found?

usually along milk line, but rarely can be found beyond mammary line

24

what are some causes of galactorrhea

excessive stimulation
hormonal dysregulation
medication side effect
underlying malignancy (30% of women > 60yo)

25

Mastitis

inflammation of parenchyma of mammary gland

26

etiology of mastitis?

inflammatory or infectious

27

What are top 3 bacteria that cause infectious mastitis?

#1 staph areus
#2 staph epidermitis
#3 strep epidermitis

28

puerperal mastitis

during pregnancy or right after

29

what pt population is more likely to get peri-ductal mastitis?

Smokers (90% of pt are smokers)

30

histology of periductal mastitis

keritinizing squamous epithelium in the duct system of the nipple that extends to abnormal depth