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Flashcards in FINAL: Cardiac Physiology Deck (22)
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Aortic insufficiency

increases pulse pressure and decreases diastolic pressure


If systolic pressure is 130 mmHg and diastolic pressure is 82 mmHg an estimate of mean arterial pressure in mmHg is:



Pulse Pressure is

determined by stroke volume


The greatest pressure decrease in the circulation occurs across the arterioles because

they have the greatest resistance


The pulmonary circlulation is similar to the systemic circulation is one important respect

the same volume of blood flows through the pulmonary vessels and systemic vessels per unit of time


Which of the following structure in the resting subject receives the greatest blood flow per gram of tissue (specific blood flow)?



With a cardiac output of 5.6 L/min and a heart rate of 70 beats/min the stroke volume in mL/beat is:



If the ventricular Purkinje fibers become the pacemaker of the heart, what is the expected heart rate?



If there is a failure in conduction of the S-A nodal impulse to the A-V node or if the S-A node stops firing, the A-V node will take over as the pacemaker of the heart. The intrinsic rhythmical rate of the A-V node is 40 to 60 times per minute. If the Purkinje fibers take over as pacemakers, the heart rate will be between 15 and 40 beats/min.


What is the membrane potential (threshold level) at which the S-A node discharges?

The normal resting membrane potential of the S-A node is -55 mV. As the sodium leaks into the membrane an upward drift of the membrane potential occurs until it reaches -40 mV. This is the threshold level that initiates the action potential at the S-A node.


What is the resting membrane potential of the sinus nodal fibers?



Which of the following are caused by acetylcholine?

Hyperpolarization of the S-A node


Which of the following best explains how sympathetic stimulation affects the heart?

The rate of upward drift of the resting membrane potential of the S-A node increase


Which of the following conditions at the A-V node will cause a decrease in heart rate?

Increased potassium permeability

An increase in potassium permeability causes a decrease in the membrane potential of the A-V node. Thus, it will be extremely hyperpolarized, making it much more difficult for the membrane potential to reach its threshold level for conduction. This results in a decrease in heart rate. Increases in sodium and calcium permeability and norepinephrine levels increase the membrane potential, causing a tendency to increase the heart rate.


Systemic arterial pressure in the adult is approximately 6-fold that of pulmonary arterial pressure because

systemic resistance exceeds pulmonary resistance
Response Feedback:

Pressure = resistance X flow. Because the flow from the left ventricle approximately equals the flow from the right ventricle, resistance becomes the determining factor. Right and left ventricular stroke volumes are approximately equal.


Compared to rest conditions exercise causes the biggest increase in blood flow in:

Muscle and skin


he French physician Jean L.M. Poiseuille (1799-1869) defined the factors that regulate the flow of water through a single, rigid cylindrical tube. Which of the following is correct with regard to flow rate as expressed in the Poiseulle equation?

directly proportional to the radius to the fourth power


The total resistance offered by three resistances (0.2, 0.4, and 0.2) arranged in parallel would be

0.08 PRU


An increase in arteriolar resistance, without a change in any other component of the cardiovascular system, will produce

an increase in arterial pressure

An increase in arteriolar resistance will increase total peripheral resistance (TPR). Arterial pressure=cardiac output X TPR, so arterial pressure will also increase. Capillary filtration decreases when there is arteriolar constriction because Pc decreases. Afterload of the heart would be increased by an increase in TPR.


alculate the total peripheral resistance of an individual from the following measured variables:

Mean arterial pressure = 100 mm Hg

Central venous pressure = 0 mm Hg

Cardiac output = 5L/min

In peripheral resistance units (mm Hg/L/min), the total peripheral resistance of this individual is:



In the figure below, assume that pressure at entrance to segment A is maintained at 100 mm Hg, whereas that at the ends of segments B and C is 0 mm Hg. Assume the numbers listed for each segment represent resistance for the segment in PRUs. Which of the following with increase blood flow through segment C?

Decreasing resistance in segment C to 1 PRU

At constant pressure, the flow through the entire circuit is inversely proportional to resistance. Any factor that decreases total resistance will increase total flow through the system, but flow is diverted through the branches in inverse ratio of their resistances. Option B decreases total resistance and favors flow through segment C over through segment B.


The tendency for blood flow to be turbulent is increased by:

PARTIAL occlusion of a blood vessel

Turbulent flow is predicted when the Reynolds number is increased. Factors that increase the Reynolds number and produce turbulent flow are decreased viscosity (hematocrit) and increased velocity. Partial occlusion of a blood vessel increases the Reynolds number (and turbulence) because the decrease in cross-sectional area results in increased blood velocity (v=Q/A)


The variable that is most responsible for the change in resistance to blood flow in a healthy individual is the:

radius of the arterioles.

Although all of the factors listed will affect resistance, in the systemic circuit, resistance is varied by controlling the radius of the arterioles.
Resistance is inversely proportional to the fourth power of the vessel radius.