Final Cytokines

Question 1

TNF

Answer 1

pro - inflamm. 
made by monocytes and macrophages
induced by LPS
FXN in EC to increase adhesion proteins 
primary mediator of septic shock 
activates N 
has two R TNFR I - p75 and TNFR II- p55
anti tumor efffects in tumor cells

Question 2

IL - 1

Answer 2

pro - inflamm. 
made by monocytes and macrophages 
FXN in CNS to induce fever, lethargy, sleep, anorexia 
Same in EC as TNF (after) 
IL-2 production 
Production of APP (after IL-6) 
neutralized by IL-1ra

Question 3

IL - 6

Answer 3

pro - inflamm. 
produced by phagocytic cells 
induction of APP 
can induce fever (after IL-1) 
stimulates B cells to become plasma cells 
primary role in TH17 immune regulation

Question 4

IL - 8

Answer 4

pro - inflamm.
produced by macrophages
only attracts N and also activates them

Question 5

IL - 12

Answer 5

pro - inflamm. 
produced by DC and macrophages 
heterodimer IL12p40 and IL 12p35
fxn to stimulate NK cells 
synergizes with IL-18 to increase IFN gamma production

Question 6

IL - 15

Answer 6

pro - inflamm.
produced by phagocytes
fxn to activate NK cells, T cell GF, T lymphocyte chemoattractant
key in the survival of T memory cells

Question 7

IFN gamma

Answer 7

pro - inflamm.
produced by TH1 and NK cells
important to innate and adaptive immunity
very important in cell mediated immunity
fxn to activate macrophages
small antiviral activity
stimulates - killing by NK and N cells, MHC I and II expression, ag presentation by APP and cytokine production by APP, expression of ICAM
inhibits allergic response through IL - 4

Question 8

IL - 10

Answer 8

anti - infamm.
produced by macrophages, B cells, T regulatory cells
inhibits production of IL - 1beta, IL - 6, 8, 12, and TNF alpha
inhibits expression of MHC II, CD 80, and 86
inhibits TH1 production of INF gamma and TNF beta and TH2 production of IL - 4,5
controls tolerance to enviorn. allergies

Question 9

TGF beta

Answer 9

anti - inflamm.
most pleiotropic of cytokines
produced by macrophages and T regulatory cells
stimulates - fibrosis (wound healing)
inhibits - proliferation of B cells and CD8 cells, macrophages and NK cells
induces apoptosis in B cells, CD8 cells
regulates the differentiation of TH17

Question 10

IL - 2

Answer 10

adaptive immunity
increase T cell production
produced by CD4 and CD8 T cells

Question 11

IL - 4

Answer 11

adaptive immunity
B cell switching to IgE
produced by CD4 and mast cells

Question 12

IL - 5

Answer 12

adaptive immunity
activation of Esinoph.
produced by CD4 and mast cells

Question 13

IL - 17

Answer 13

adaptive immunity
stimulation of acute inflammation
produced by CD4