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Final Drug MOA Flashcards

(64 cards)

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1
Q

Oxybutynin

A

mACh (-)

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2
Q

Botulinum toxin

A

presynaptically blocks ACh release

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3
Q

Bethanechol

A

mACh (+)

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4
Q

Ondansetron

A

5-HT3 (-)

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5
Q

Metoclopramide

A

D (-)
5-HT3 (-)

5-HT4 (+)

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6
Q

Promethazine

A

D (-)
mACh (-)
H1 (-)

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7
Q

Scopolamine

A

mACh (-)

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8
Q

Diphenhydramine

A

H1 (-)

mACh (-)

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9
Q

Lorazepam

A

GABAa (+)

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10
Q

Tropicamide

A

mACh (-)

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11
Q

Phenylephrine

A

A1 (+)

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12
Q

Benoxinate (oxybuprocaine)

A

BLOCKS volt gated Na cannels in pain and other sensory fibers of the ophthalmic division of the trigeminal nerve on the cornea

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13
Q

Fluorescein

A

Yellow dye - stains cornea on epithelial surface

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14
Q

Dextromethropan + Quinidine

A

DXM:

  • serotonergic: neuromodulating properties
  • NMDA-R (-)
  • Sigma1-R (+): inhib glutamate transmission

Q:
(-) 1st pass metab of DXM

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15
Q

Amitriptyline

A

NET (-)
SERT (-)

mACh (-)
A1 (-)
H1 (-)

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16
Q

Fluoxetine

A

SERT (-)

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17
Q

Duloxetine

A

SERT (-)

NET (-)

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18
Q

Bupropion

A

NDRI:
NET (-)
DAT (-)

Non-stimulant

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19
Q

Trazodone

A

SERT (-) but weak
5-HT2A (-)
H1 (-)

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20
Q

Lithium

A

mech unclear

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21
Q

Divalproex

A

Inc inactive state of volt gated Na+ channels

Block T type Ca channels

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22
Q

Carbamazepine

A

Inc inactive state of volt gated Na+ channels

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23
Q

Quetiapine

A

D2 (-)

5-HT2a (-)

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24
Q

Diazepam

A

GABAa (+)

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25
Buspirone
``` Partial 5-HT1a (+) Partial D2 (+) ```
26
Propranolol
B blocker
27
Naltrexone
Opioid (-) Inhib rewarding effect of EtOh/opioid by blocking μ, kappa, and sigma
28
Naloxone
opioid (-)
29
Acamprosate
GABA analog Dec glutamate transmission and attenuate neuronal hyperexcitability during withdrawal
30
Methadone
mu opoid (+)
31
Buprenorphine
partial mu (+)
32
Nicotine
Slowly absorbed preparations
33
Varenicline
partial nicotine-R (+) | dopaminergic neurons of VENTRAL TEGMENTAL area to block reward
34
Phenytoin
Inc inactive state of Na+ channel
35
Lamotrigine
Inc inactive state of Na+ channel Blockade of T-Type Ca2+ channel
36
Topiramate
Inc inactive state of Na+ channel Potentiate effec of GABA on GABAa -R Blocks AMPA-R
37
Ethosuximide
Blockade of T-type Ca2+ channel
38
Phenobarbital
Inc opening timeof GABA channel opening
39
Primidone
Inc opening time of GABA channel opening
40
Gabapentin
Enhanace GABAergic transmission Binds to A2-Delta subunite of volt gated Ca channels May dec glutamate release
41
Levetiracetam
Modify exocytosis of glutamate and GABA via vesicle
42
Zolpidem
Novel BDZ-R (+) | GABAa (+)
43
Ramelteon
Melatonin-R (MT2 & MT2) (+)
44
Suvorecant
Orexin-R (-)
45
Amphetamine
Taken u by NET, DAT, & SERT & partly by diffusion through cell membrane --> interfere w VMAT & deplete the synaptic vesicles of monoamine NT --> monoamine released into synapse by NET, DAT, & SERT & reuptake inhibited
46
Methylphenidate
NET (-) | DAT (-)
47
Modafinil
MOA not understood ``` May: NET (-) DAT (-) Inc NE, DA, Serotonin, Glutamate Dec GABA ```
48
Sodium Oxybate
Act similarly to GHB Acts onGHA-R and GABAb-R CNS depressant
49
Atomoxetine
Non-stimulant | NET (-)
50
Clonidine
A2 (+)
51
Thiopental
GABA (+)
52
Propofol
GABA (+)
53
Etomidate
GABA (+)
54
Midazolam
GABA (+)
55
Fentanyl
mu opioid (+)
56
Ketamine
NMDA (-) | "Dissociate anesthetic"
57
Nitrous Oxide
NMDA (-) Consciousness: noncompetitive Analgesia: opioid &/or adrenergic neurons in brainstem
58
Desflurane
Multiple sites including GABAa
59
Succinylcholine
Inc depolarization of motor end plate --> neuromuscular (DEPOLARIZATION) blockade
60
Vecuronium
Nicotinic cholinergic - R (-) on motor end plate
61
Haloperidol
D1 (-)
62
Aripiprazole
D2 (-) | 5-HT2a (-)
63
Donepezil
ACh-I
64
Memantine
NMDA (-) | MOA unclear

Neuro (9 decks)

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