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Neuro > Final Drug MOA > Flashcards

Final Drug MOA Flashcards

1
Q

Oxybutynin

A

mACh (-)

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2
Q

Botulinum toxin

A

presynaptically blocks ACh release

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3
Q

Bethanechol

A

mACh (+)

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4
Q

Ondansetron

A

5-HT3 (-)

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5
Q

Metoclopramide

A

D (-)
5-HT3 (-)

5-HT4 (+)

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6
Q

Promethazine

A

D (-)
mACh (-)
H1 (-)

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7
Q

Scopolamine

A

mACh (-)

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8
Q

Diphenhydramine

A

H1 (-)

mACh (-)

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9
Q

Lorazepam

A

GABAa (+)

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10
Q

Tropicamide

A

mACh (-)

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11
Q

Phenylephrine

A

A1 (+)

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12
Q

Benoxinate (oxybuprocaine)

A

BLOCKS volt gated Na cannels in pain and other sensory fibers of the ophthalmic division of the trigeminal nerve on the cornea

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13
Q

Fluorescein

A

Yellow dye - stains cornea on epithelial surface

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14
Q

Dextromethropan + Quinidine

A

DXM:

  • serotonergic: neuromodulating properties
  • NMDA-R (-)
  • Sigma1-R (+): inhib glutamate transmission

Q:
(-) 1st pass metab of DXM

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15
Q

Amitriptyline

A

NET (-)
SERT (-)

mACh (-)
A1 (-)
H1 (-)

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16
Q

Fluoxetine

A

SERT (-)

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17
Q

Duloxetine

A

SERT (-)

NET (-)

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18
Q

Bupropion

A

NDRI:
NET (-)
DAT (-)

Non-stimulant

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19
Q

Trazodone

A

SERT (-) but weak
5-HT2A (-)
H1 (-)

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20
Q

Lithium

A

mech unclear

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21
Q

Divalproex

A

Inc inactive state of volt gated Na+ channels

Block T type Ca channels

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22
Q

Carbamazepine

A

Inc inactive state of volt gated Na+ channels

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23
Q

Quetiapine

A

D2 (-)

5-HT2a (-)

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24
Q

Diazepam

A

GABAa (+)

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25
Q

Buspirone

A 
Partial 5-HT1a (+)
Partial D2 (+)
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26
Q

Propranolol

A

B blocker

27
Q

Naltrexone

A

Opioid (-)

Inhib rewarding effect of EtOh/opioid by blocking μ, kappa, and sigma

28
Q

Naloxone

A

opioid (-)

29
Q

Acamprosate

A

GABA analog

Dec glutamate transmission and attenuate neuronal hyperexcitability during withdrawal

30
Q

Methadone

A

mu opoid (+)

31
Q

Buprenorphine

A

partial mu (+)

32
Q

Nicotine

A

Slowly absorbed preparations

33
Q

Varenicline

A

partial nicotine-R (+)

dopaminergic neurons of VENTRAL TEGMENTAL area to block reward

34
Q

Phenytoin

A

Inc inactive state of Na+ channel

35
Q

Lamotrigine

A

Inc inactive state of Na+ channel

Blockade of T-Type Ca2+ channel

36
Q

Topiramate

A

Inc inactive state of Na+ channel

Potentiate effec of GABA on GABAa -R

Blocks AMPA-R

37
Q

Ethosuximide

A

Blockade of T-type Ca2+ channel

38
Q

Phenobarbital

A

Inc opening timeof GABA channel opening

39
Q

Primidone

A

Inc opening time of GABA channel opening

40
Q

Gabapentin

A

Enhanace GABAergic transmission

Binds to A2-Delta subunite of volt gated Ca channels

May dec glutamate release

41
Q

Levetiracetam

A

Modify exocytosis of glutamate and GABA via vesicle

42
Q

Zolpidem

A

Novel BDZ-R (+)

GABAa (+)

43
Q

Ramelteon

A

Melatonin-R (MT2 & MT2) (+)

44
Q

Suvorecant

A

Orexin-R (-)

45
Q

Amphetamine

A

Taken u by NET, DAT, & SERT & partly by diffusion through cell membrane –> interfere w VMAT & deplete the synaptic vesicles of monoamine NT –> monoamine released into synapse by NET, DAT, & SERT & reuptake inhibited

46
Q

Methylphenidate

A

NET (-)

DAT (-)

47
Q

Modafinil

A

MOA not understood

May:
NET  (-)
DAT (-)
Inc NE, DA, Serotonin, Glutamate
Dec GABA
48
Q

Sodium Oxybate

A

Act similarly to GHB
Acts onGHA-R and GABAb-R

CNS depressant

49
Q

Atomoxetine

A

Non-stimulant

NET (-)

50
Q

Clonidine

A

A2 (+)

51
Q

Thiopental

A

GABA (+)

52
Q

Propofol

A

GABA (+)

53
Q

Etomidate

A

GABA (+)

54
Q

Midazolam

A

GABA (+)

55
Q

Fentanyl

A

mu opioid (+)

56
Q

Ketamine

A

NMDA (-)

“Dissociate anesthetic”

57
Q

Nitrous Oxide

A

NMDA (-)

Consciousness: noncompetitive

Analgesia: opioid &/or adrenergic neurons in brainstem

58
Q

Desflurane

A

Multiple sites including GABAa

59
Q

Succinylcholine

A

Inc depolarization of motor end plate –> neuromuscular (DEPOLARIZATION) blockade

60
Q

Vecuronium

A

Nicotinic cholinergic - R (-) on motor end plate

61
Q

Haloperidol

A

D1 (-)

62
Q

Aripiprazole

A

D2 (-)

5-HT2a (-)

63
Q

Donepezil

A

ACh-I

64
Q

Memantine

A

NMDA (-)

MOA unclear

Neuro (9 decks)

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