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final: endocrin Flashcards

1
Q

Oxytocin (pitocin) action

A

mimics oxytocin that naturally occurs in the body

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2
Q

Oxytocin (pitocin) use

A
  • induces or augments labor by increasing strength, frequency and length of uterine contractions
  • control of postpartum bleeding
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3
Q

Oxytocin (pitocin) SE

A
  • hyperstimulation (bad for baby)
  • uterine rupture
  • post delivery atony when used intrapartum (risk for bleeding)
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4
Q

caution for Oxytocin (pitocin)

A

potentiates hypersensitive effects of other drugs

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5
Q

dinoprostone (cervidil) class

A

synthetic prostaglandin

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6
Q

dinoprostone (cervidil) admin

A

inserted into vagina and placed near the cervix

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7
Q

dinoprostone (cervidil) use

A
  • ripens (softens) cervix

- induces contractions

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8
Q

dinoprostone (cervidil) SE

A
  • N/V
  • fever
  • uterine rupture
  • hyperstimulation
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9
Q

dinoprostone (cervidil) contraindications

A

previous c-section

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10
Q

Magnesium sulfate decreases…

A
  • uterine contraction
  • neuromuscular conduction
  • acetylcholine release
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11
Q

Magnesium sulfate causes

A

vasodialation

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12
Q

Magnesium sulfate use

A
  • premature onset of labor

- pre-eclampsia and eclampsia

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13
Q

Magnesium sulfate SE

A
  • CNS depression, heart and reflex depression
  • flushing, sweating, hypotension
  • flaccid paralysis
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14
Q

Magnesium sulfate contraindications:

A

additive effect with CNS depressants

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15
Q

Conjugated Estrogen (premarin) class

A

mimics hormone estrogen

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16
Q

Conjugated Estrogen (premarin) use

A

relieve vasomotor symptoms of menopause

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17
Q

warning with Conjugated Estrogen (premarin)

A
  • use shortest time possible

- if you have a uterus you must take progestin to prevent endometrial buildup that leads to endometrial cancer

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18
Q

Conjugated Estrogen (premarin) SE

A
  • GI
  • fluid retention
  • wt gain
  • depression
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19
Q

BBW with Conjugated Estrogen (premarin)

A

increased risks of thromboembolic events, stroke

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20
Q

causes dementia in postmenopausal women

A

Conjugated Estrogen (premarin)

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21
Q

Conjugated Estrogen (premarin) contraindications

A
  • liver disease
  • those at risk for above disorders
  • Hx of repro cancer
  • smoking
  • fibroids
  • undiagnosed vaginal bleeding
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22
Q

Conjugated Estrogen (premarin) interacts with

A
  • anticonvulsants
  • barbiturates
  • rifampin
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23
Q

Medroxyprogesterone acetate (provera, Depo-Provera) class

A

synthetic progestin that mimics naturally occurring hormone progesterone

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24
Q

Medroxyprogesterone acetate (provera, Depo-Provera) use

A

○ Decrease hyperplasia of uterine lining
○ Changes proliferative endometrium into secretory
○ Suppress pituitary hormones to inhibit ovulation (Depo Provera)

25
Medroxyprogesterone acetate (provera, Depo-Provera) SE
○ Headache/ Migraines/ Depression/Vision changes/loss/Weight gain ○ Irregular vaginal bleeding ○ GI Upset with nausea and vomiting
26
Medroxyprogesterone acetate (provera, Depo-Provera) BBW
- increased risk of cardiac complications, thromboembolic events - bone loss with depo provera
27
Medroxyprogesterone acetate (provera, Depo-Provera CI
○ CV disease ○ Hx of thromboembolic event or cerebral hemorrhage ○ renal disease (progestin metabolites excreted in urine) ○ hepatic disease (metabolism of progestin occurs in liver)
28
conjugated estrogen-medroxyprogesterone (prempro) is a combo of what two drugs
- conjugated estrogen (premarin) | - medroxyprogesterone acetate (provera)
29
conjugated estrogen-medroxyprogesterone (prempro) was created for which women
those with intact uterus who need to take progestin with estrogen HRT to reduce endometrial hyperplasia and subsequent risks
30
conjugated estrogen-medroxyprogesterone (prempro) risks
same risks as each med individually
31
estradiol and norethrindrone (ortho-novum) is also called
"the pill"
32
estradiol and norethrindrone (ortho-novum) class
synthetic estrogen and progestin used to suppress menstrual cycle
33
estradiol and norethrindrone (ortho-novum) use
- contraception - achne - PMDD - menstrual disorders
34
estradiol and norethrindrone (ortho-novum) SE
- N/V - thromboembolism/mi/stroke/cardiovascular - gallbladder disease - edema/wt gain/headache
35
estradiol and norethrindrone (ortho-novum) CI
- 35+ smoking - liver issues - reproductive cancers in family (breast) - clot Hx - migraine with aura
36
estradiol and norethrindrone (ortho-novum) interactions
- antibiotics - anticonvulsants - barbiturates - griseofulvin these increase chance of pregnancy
37
Alendronate (Fosamax) class
bisphosphonate
38
Alendronate (Fosamax) use
osteoprosis
39
Alendronate (Fosamax) MOA
suppresses osteoclasts: | -osteoclast are bone cells that absorb bone in the process of bone turnover
40
Alendronate (Fosamax) SE
-esophagitis, dysphagia, esophageal ulcers -headache -muscle pain -decreased serum calcium -atypical femur fracture osteonecrosis of the jaw
41
Alendronate (Fosamax) admin
with FULL glass of WATER (not juice) - 30 min before breakfast or other drugs - stay upright 30 mins after to promote absorption and decrease gastric irritation
42
Alendronate (Fosamax) contraindications
must be able to sit for 30 mins | -no renal impairment
43
Alendronate (Fosamax) interactions
-no ASA, NSAIDS, Antacids and Ca+2 hours apart
44
testosterone class
man made version of naturally occurring testosterone in the body
45
testosterone use
-androgen deficiency
46
testosterone SE
MASCULINE CHARACTERISTICS - acne - hairloss - headache - hypercalcemia - bitter taste, mouth irritation, gum tenderness - jaundice - edema
47
testosterone contraindications
- liver disease | - prostate issues
48
Sildenafil (viagra) class
PDE 5 inhibitor
49
Sildenafil (viagra) uses
enhances erection by increasing bf to penis
50
Sildenafil (viagra) onset
20-60 minutes and lasts up to 4 hours
51
Sildenafil (viagra) taken
once in a 24 hr period
52
Sildenafil (viagra) SE
``` ○ Increased risk of hypotension ○ Headache ○ Facial flushing ○ Dyspepsia ○ nasal congestion ○ Dizziness ○ Permanent loss of vision (rare), loss of hearing (rare) ○ Priapism (Persistent and painful erection) ```
53
Sildenafil (viagra) interactions
- nitrated - alpha blockers - antifungals - erythromycin - antiviral
54
Sildenafil (viagra) absorption is decreased by
fatty foods and booze
55
Finasteride (Proscar) class
5 alpha reductase inhibitor -anti-testosterone drug
56
Finasteride (Proscar) use
-benign prostatic hyperplasia | shrinks prostate so urine can pass
57
Finasteride (Proscar) SE
- sexual dysfunction | - feminine characteristics enhanced in men
58
Finasteride (Proscar) cautions
- preggo women shouldn't touch this med - children shouldn't take - can not give blood while taking
59
Finasteride (Proscar) interactions
- testosterone - anticholinergics - saw palmetto (herbal)

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