Final Exam Flashcards
(183 cards)
Stochastic effects
Cell DNA injury
No threshold
-All or non response
In stochastic effects the greater the does
Increases the probability of occurrence
Any amount of radiation
Deterministic effect
High amount of radiation
- Increased cell death
- Threshold does
Threshold dose
(Deterministic effect)
Clinical symptoms apparent at any dose above threshold
Severity is PROPORTIONAL to dose
2 types of effects from formation of free radicals
Direct effects
Indirect Effects
Law of Bergonie and Tribondeau
Radiosensitivity of different tissues
- Amount of undifferentiated cells
- Mitosis activity
- Length of active proliferation
Oocytes and lymphocytes
What cells have the highest radiosensitivity
Lymphoid tissues Bone marrow Testes Ovaries Small intestines
The more undifferentiated the more
Mitosis and more radiosensitive tissue that is
Oocytes and lymphocytes are highly _______ but very _____
Differentiated
Sensitive
Linear Energy Transfer
The rate at which energy from photons is imparted as they travel through matter
High LET
Densely ionizing
Low LET
Sparsely ionizing
As energy is given off
Different damage is done
Absorbed Dose
Measure of the total energy transferred from any type of radiation to matter
rad or Gy
100 rads =
1 Gy
Equivalent Dose
Measure of how different types of radiation affect various tissues
-Sv
Radiation sighting factor (Wr)
1 Sv=
1 Gy
Effective Dose
Measure of estimated risk in humans
-Sv
Tissue weighting factor (Wt)
Acute Radiation Syndrome
Whole Body irradiation
Onset is ore rapid and severity increases with greater dose
Management depends on stage
Mucositis
Second week of therapy
Erythematous mucosa Sloughing of the irradiated tissue Painful Secondary infection Difficulty consuming food Heals within 2 months after completion of radiotherapy
Xerostomia
Parenchuymal cells of salivary glands are radiosensitive
Reduced salivary flow
Pain/tenderness
Difficulty chewing and swallowing
May resolve in 6-12 months
Taste Loss
Second/third week of therapy
Reduced salivary flow my a contributing factor
Reversible
Trips us
Inflammation and fibrosis of musculature
Limited opening 2 months after completion of radiation therapy
PT
MOM affected
Radiation Caries
Rampant tooth decay
-mostly due to salivary gland changes
Maintenance and compliance
-daily fluoride varnish