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Flashcards in Final Exam Deck (34)
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1

Staph aureus

Gram positive

2

MRSA

Gram positive

3

MSSA

Methicillin susceptible, gram positive

4

Strep pneumonia

CAP, gram positive

5

Strep pyogenes

Group A strep, strep throat, necrotizing fasciitis, gram positive

6

Enterococcus faecalis

Gram positive

7

Enterococcus faecium

Gram positive

8

Cdiff

Gram positive, anaerobic

9

Gram positive organisms are what color?

Purple

10

Gram negative organisms are what color?

Pink

11

E. Coli

Gram negative

12

Klebsiella pneumonia

Gram negative

13

Pseudomonas aeruginosa

Gram negative

14

Bacteroides fragiles

Gram negative; anaerobic

15

MIC

Minimum inhibitory concentration, lowest amount of drug that will inhibit growth of organism

16

Time dependent

Greater bactericidal activity as drug concentration remains above the MIC (in time)

17

Concentration dependent

Greater bactericidal activity as drug concentration Cmax exceeds MIC

18

MOA PCN

Inhibits cell wall synthesis

19

HX of PCN

Belongs to beta lactam family, PCN V PO, PCN G IV/IM; as time went on...increasing spectrum of gram- organisms added to PCN. Originally only gram + susceptible

20

PCN origination

1928 discovered, Staph aureus, streptococcus spp., syphilis. Initially great for skin infxn - until resistance. Rx of choice for syphilis.

21

Pen G

IV penicillin

22

Pen G benzathine

IM

23

Pen V

PO PCN - low absorption, limiting its use

24

Oxacillin, Nafcillin, Dicloxacillin

Anti-Staphylococcal PCNs... Tx for PCN-resistant staph aureus (d/c methicillin d/t hepatotoxicity)

25

Drug of choice for MSSA infections (blood stream)

Anti-staphylococcal PCNs - oxacillin, nafcillin, dicloxacillin

26

Oxacillin, nafcillin, dicloxacillin metabolism

Cleared by liver - no renal adjustments (unique); short half life - dosed q4h

27

PO anti-staph PCN

Dicloxacillin - not common; req freq dosing

28

GPC in chains

Strep (chained down when you have strep)

29

GPC in clusters

Staph (cluster the MRSA)

30

What does an antibiogram show?

Number listed is percent of organisms susceptible to antibiotic listed