final push

Question 1

CML chromosome and fusion gene

Answer 1

9:22, philadelphia chromosome, BCR-ABL fusion

Question 2

MOA of imatinib for CML

Answer 2

TKi - check renal function, LFTs, interactions, Qtc prolongation

Question 3

infection consideration for CML and why adherance

Answer 3

vaccine review

loss of molecular response, disease progression and resistance

Question 4

teams in pancreatic cancer

Answer 4

hepatopancreatobiliary surgeons, oncology, palliative care, Gastroenterology for stenting, dietician

Question 5

obstructive jaundice complications

Answer 5

pruritic, coagulopathy (Vit K malabsorption), steatorrhoea, cholangitis

Question 6

can’t have surgery in pancreatic cancer next step

Answer 6

stent

Question 7

reasons for discussion in early supportive care planning

Answer 7

understanding of prognosis, symptom control plans, advance care planning, respect form for DNACPR

Question 8

palliative indications

Answer 8

local spread, poor prognosis, symptom burden, likely progression, emotional needs

Question 9

pancreatic cancer complications

Answer 9

cholangitis, biliary sepsis, VTE