Finals Flashcards
What does insulin do
It allows the cells to use glucose. Even though the blood glucose is high the cells cannot use the glucose so they break down fat and use protein from the lean body mass
Why is insulin secreted by the pancreas
In response to increasing glucose levels
What is special about insulin
It is the only hormone to lower blood glucose. Causes blood glucose uptake by cells
Which hormones cause blood glucose to rise
Glucagon, Adrenaline, cortisol, growth hormone
What is type one diabetes
Insulin-dependent diabetes more common in dogs. Pancreas is not producing enough insulin usually because of immune destruction of the beta cells of the pancreas
What is type two diabetes
Non-insulin-dependent diabetes. Insulin resistance. The receptors on the cells do not respond to insulin
Are cats or dogs more likely to get type 2 diabetes
Cats
Which diabetes is associated with obesity
Type two. Fat cells hide receptors for insulin
What are the predisposing factors for diabetes
Obesity, middle age, genetics, other hormones. Elevated levels of Cortizone, progesterone can cause insulin resistance
Describe carbohydrate metabolism in cats
They only have one enzyme so it takes longer to clear the glucose from the blood
What are the clinical signs of diabetes
Polyphagia, polyuria polydipsia, weight loss, cataracts in dogs, polyneuropathy, Plantigrade posture in cats, prone to bacterial infections, hyperglycemia, glucosuria, hepatic lipidosis, renal disease
What is the goal in treatment for diabetes
Stabilize glucose levels without causing hypoglycemia. Minimize hyperglycemia, provide optimal amount of nutrients, minimize clinical signs, avoid hypoglycemia
What is the blood glucose concentration normally for dogs
5-10 to 12 mmol/l
What is the blood glucose concentration normally for cats
5-14-16 mmol/l
What is the renal threshold
14 mmol per liter
What is the normal blood glucose range in non-diabetic cats
2.6 to 8.4 mmol per liter
What is the goal of an ideal blood glucose curve
To produce a blood glucose curve that approaches the reference range but avoids potentially fatal hypoglycemia for example 5 to 14mmol for most of each 24 hour period.
What is the three important dietary treatments for diabetes
Be consistent with amounts, consistent time in consistent ingredients consistent proportion of carbohydrates fat and protein. Slow absorption of glucose from the intestine by having a food low in simple sugars high in complex carbohydrates such as barley to slow glucose absorption. Add fiber to slow gastrointestinal transit time.
What should a diabetic diet have
Good quality and quantity of protein to protect lean body mass will also provide amino acids for gluconeogenesis. Antioxidants such as vitamin E, fat content will depend on body score: obese versus skinny diabetics
What nutraceutical should a diabetic diet contain
Chromium to use insulin better, Carnithine to help with fat metabolism, antioxidants
How do you reduce glucose elevations in cats
Reduce carbohydrate and increase protein to result in slower glucose elevations
What are some common causes of critical illness
Trauma, neoplasia, anemia, organ failure, sepsis, central nervous system disease, toxins, immune mediated diseases
How is starvation different in the sick animal
A sick animal up regulates its metabolism in spite of starvation
What happens when a healthy animal is in starvation
It down regulates its metabolism in the face of starvation because he wants to conserve energy
What happens to the G.I. tract during starvation
The intestinal villi get nutrition directly from intestinal contents. If there’s no food in the G.I. tract you get Villas atrophy where you cannot digest and absorb food, greater chance of bacterial translocation. Also due to starvation the stomach shrinks.
What happens in starvation
The body uses that stores for energy. Sacketts metabolized into key tones which may be used as an energy source in some tissues. As there’s no storage form of protein in the body muscle proteins are cannibalized into energy. This results in the loss of lean body mass. There’s a rapid loss of lean body mass in the anorexic sick animal.
What does a sick Animal need
Increased protein
What diet does an anorexic sick Animal need
High-quality protein and high energy (fat)