FINALS: Nonmalignant Granulocytic Disorders Flashcards Preview

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Flashcards in FINALS: Nonmalignant Granulocytic Disorders Deck (94)
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1

Redistribution of the blood pools cause a short-term increased in the total WBC count and in the absolute number of neutrophils in the circulating granulocyte pool.

Shift/physiologic/pseudoneutrophilia

2

Caused by exercise, stress, pain, pregnancy

Shift/physiologic/pseudoneutrophilia

3

It is not a response to tissue damage. The total blood granulocyte pool in the body has not changed.

Shift/physiologic/pseudoneutrophilia

4

The bone marrow has not released immature neutrophils. There are no toxic changes. And there is ______ to the left.

no shift

5

Neutrophils leave the circulating pool, enter the marginating pool, and then move to the tissues in response to tissue damage

Pathologic neutrophilia

6

In pathologic neutrophilia, bone marrow reserves are _____ to replenish the circulating pool and ______ production of neutrophils to replenish reserves.

released
increases

7

Occurs in response to bacterial and the other infections, tissue destruction, drugs or toxins, growth factor, etc.

Pathologic neutrophilia

8

Blood picture mimics that seen in chronic myelogenous leukemia.

Neutrophilic leukemoid reaction (NLR)

9

Benign, extreme response to a specific agent of stimulus

Neutrophilic leukemoid reaction (NLR)

10

In neutrophilic leukemoid reaction (NLR), the WBC count can _____ to between 50.0 and 100.0×〖10〗^9/L, and there is a ______ with ______ changes to the neutrophils.

increase
shift to the left
toxic

11

Characterised by having the presence of immature leukocyte and immature (nucleated) erythrocytes in the blood

Leukoerythroblastic reaction

12

Occurs in marrow replacement disorders, such as myelofibrosis

Leukoerythroblastic reaction

13

Decrease in absolute number of neutrophils

Neutropenia

14

Due to bone marrow production defects chronic or severe infection depletes available neutrophil reserves. Use exceed bone marrow production

Neutropenia

15

____ causes neutrophils to be removed from circulation

Hypersplenism

16

Neutropenia can be cause by one of the ff:

bone marrow injury (aplastic anemia),
bone marrow infiltration (leukemia, myelodyplastic syndromes or mestatistic cancer),
bone marrow suppression by chemicals or drugs (chemotheraphy)

17

Neutropenia can be cause by DNA synthesis defects due to

vitamin B12 or folate deficiency

18

Increase in the absolute number of eosinophils

Eosinophilia

19

Associated with parasitic infections, allergic reactions, chronic inflammation

Eosinophilia

20

Associated with chronic myelogenous leukemia, including early maturation stages, Hodgkin disease, tumors

Eosinophilia

21

Decrease in the absolute number of eosinophils

Eosinopenia

22

Seen in acute inflammation and inflammatory reactions that cause release of glucorticosteroids epinephrine

Eosinopenia

23

Increase in the absolute number of basophils

Basophilia

24

Associated with Type I hypersensitivity reactions

Basophilia

25

Associated with chronic myelogenous leukemia, including early maturation stages, polycythemia vera

Basophilia

26

Associated with relative transient basophilia can be seen in the patient on hematopoietic growth factors.

Basophilia

27

Decrease in the absolute number of basophils associated with inflammatory states and following immunologic reactions

Basopenia

28

Chronic granulomatous disease (CGD) : Nitroblue Tetrazolium Test (NBT) is _________ inheritance with the ratio of affected males to females being 6:1

both sex-linked and autosomal recessive

29

In Chronic granulomatous disease (CGD) : Nitroblue Tetrazolium Test (NBT), granulocytes are morphologically _______, but functionally ______ because of enzyme deficiency that results in an inability to degranulate, with causes inhited bactericidal function.

normal
abnormal

30

Characterised as an autosomal recessive disorder that causes large, gray-green, peroxidase positive granules in the cytoplasm of leukocytes; abnormal fusion of primary and secondary neutrophilic granules

Chédiak-Higashi syndrome