Finals Pharmacology Flashcards Preview

6th Year PACES & Pharmacology > Finals Pharmacology > Flashcards

Flashcards in Finals Pharmacology Deck (77)
Loading flashcards...
0

Most serious toxicity work sodium valproate

Hepatic toxicity (necrotic Process)

Can cause thrombocytopenia

1

Acute cellulitis of leg. What bacteria to treat

Hemolytic streptococcus

2

Antibiotic responsible for warfarin interaction

Ciprofloxacin

3

Anticonvulsant drug with least teratogenic risk

Lamotrigine
(Carbamazepine is in middle, valproate is the worse)

Absolute risk is only 4-5%

4

Most likely adverse of verapamil at therapeutic dose

Constipation

5

Which antipsychotic most likely to cause extraoyramidal effects

Flupentixol (first generation)

Atypical cause less

6

Which is most likely adverse event of leukotriene antagonists

Effective in one third
Step 4
Once a day
One bad adverse event (church Strauss (eosinophilic vasculitis which can be fatal)

Right answer: used in exercise or cold induced asthma

7

If patient presented with af within 6 hours

Then do DC cardioversion as best initial option

8

Cancer patient prescribed morphine. What other treatment would you give

Antiemetic: hyoscine (not useful in this case,)
Laxative: co-danthramer

9

Cancer chemo that causes severe hair loss and hemorrahgic cystitis

Cyclophosphamide

10

Patient with hypertension and heart failure develop a increased breathlessness after adding one of these drugs

Verapamil (because inotrope negative (and kronotrope negative)

11

Most likely adverse effect of ciclosporin

Hypertension

12

75 year old recovers from cdiff. What to give her again?

Metronidazole 2 weeks

13

80 y old patient drowsy with lOw potassium sodium and high urea. Most likely cause

Excessive treatment with loop diuretics

14

Alcoholic:///confusion ataxia macrocytosis

Give thiamine

15

Regarding copd

Long term oxygen therapy is indicated in presence of pulmonary hypertension

Recently: inhaled steroids no significant place in therapy

16

Side effects of low Molecular weight heparin

Thrombocytopenia
Osteoporosis

17

Most effective on Post prandial hyperglycemia

Acarbose

18

Treatment of very high triglycerides (biggest risk can cause acute pancreatitis)

Fenofibrate

19

In diabetic ketoacidosis

Blood glucose should be reduced to 10 mol/l within 24 hours
Iv bicarb avoided
Prophylactic antibiotics not given
Total boys potassium is depleted
Total fluid deficit is much higher than 3 litre

20

Diarrhea as a side effect of

Misoprostol (synthetic prostaglandin analogue)

21

Potentially dangerous combination with sildenafil causing hypotension

Isosorbide mononitrate

22

Dangerous combination of fluoxetine with which of the drugs

Phenelzine (imao serotonin syndrome)

23

Which antifungal drug inhibitor of cyp450

Ketoconazole

24

Phase 2 Metabolic reaction

Glucuronidation

Phase 2 are adding molecules too small molecules

Phase 1: deanination, hydrolysis, reduxrion

25

Hepatic drug metabolism in babies

Similar to adults

26

In old

Glomerular filtration rate lower than at age of 20

27

Initial treatment of generalised tonic clinic seizure it's

Diazepam

28

Adverse effect of carvimazole

Neutropenia

29

Know type I diabetes found unconscious
What to give without knowing anything Else

50 ml glucose 20% solution via rapid intravenous injection