First class Flashcards
(25 cards)
What is extracellular matrix (ECM)
Fibrous proteins
glycosaminoglycans
What is Kinase
It phosphorylates a substrate
What gene is Marfan syndrome caused by
Fibrillin I
Common dental symptoms in Marfan
micrognalgia High arched palate Narrow thin face Severe periodontal disease. No apparent local factor TMD
What does BMP do
promotes osteoblast differentiation
Acceleration of bone formation/healing
What is the important of bone
Type I collagen
What is the initial of signal transduction
Growth factors--> Receptors(receptor kinases--> Signaling molecules--> Transcription factor--> Gene regulation/cell response
A transcription factor has to be able to
Come into nucleus
Bind to DNA
Turn something on
For signal transduction whats important
direct binding (protein-protein interaction) Protein modifications such as phosphorylation
What is phosphorylation
The addition of a phosphate
What does Smad 3 use
TGF-beta
What is trigered by signal transduction
Cell proliferation cell cycle cell differentiation Cell movement Cell death- necrosis, apoptosis Cell Clearance- Autophagy
How can you tell if cell is diff
Nucleus is at the bottom
is ciliated
Shape
What is chemotaxis
cellular movement
What is cell death
Necrosis
Apoptosis; Programed, not necessarily associated with inflammation.
What is autophagy
self destruction without inflammation
Achondropalsia
FGFR3 G380R mutation >95% of the cases in the transmembrane domain
LOW SET EARS
Hypoplastic Maxilla
Pseudo-mandibular prognathism (appears as mandibular prognathism, but under development of mid facial region) Malocclusion
Crowding of the teeth
Crouzon syndrome
Fibroblast Growth Factor Receptor (FGFR)2 or 3 mutation
High-arched palate
Pseudo-mandibular prognathism (appears as mandibular prognathism, but under development of mid facial region) Narrow palate
Crowding of the teeth
Apert syndrome
Fibroblast Growth Factor Receptor (FGFR)2 mutation
Narrow/high-arched palate
Malocclusion (i.e. Considerable permanent under bite ) due to under development of mid facial area
how mutations affect FGF signaling
FGFR MUTATION STABILIZES MUT FGFR PROTEIN
Information to make protein is coded by
Exons
Different exons are removed to make isoforms
Treacher collins syndrome
Limited got zygomatic arches and mandible
cleidocranial dysplacia
partial absence of clavicles
Mobility of shoulders
Delayed closure of the anterior fontanelles
BCNS
Hedgehog signaling disease
