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1

Direct acting adrenergic agonist; effects differ at high and low doses; causes hyperglycemia; used in anesthetics,

Epinephrine

2

Vasoconstriction including at kidney (α-1);
Both systolic and diastolic blood pressure increase, leading to a vagal mediated reflex bradycardia

Norepinephrine

3

Direct acting adrenergic agonist --- at low concentrations;
1 receptor leads to vasodilation --- at higher concentrations a positive inotropic effect on the myocardium is seen (beta-1)

Dopamine

4

selective D1 agonist

Fenoldopam

5

Non-selective β-adrenergic agonist;
β1 -> increase in HR;
β2 -> vasodilation of skeletal muscles, alleviates acute attacks of asthma

Isoproterenol

6

Selective β1-adrenergice agonist administered as a racemic mixture;
used to increase cardiac output in acute management of HF

Dobutamine

7

β2-selective adrenergic agonist; contains a resorcinol ring so is not a substrate for COMT -> long acting;
USES: reduce uterine contractions in premature labor

Terbutaline

8

β2-selective adrenergic agonist;
USES: inhalant to relieve bronchospasm

Albuterol

9

β2-selective adrenergic agonist;
USES: inhalant to relieve bronchospasm with a long duration of action (12 hours)

Salmeterol

10

β2-selective adrenergic agonist;
USES: inhalant to relieve bronchospasm with a long duration of action (12 hours)

Formoterol

11

α1-selective adrenergic agonist; no direct effect on the heart, but induces reflex bradycardia when given parenterally; USES: nasal decongestant

Phenyleprine

12

α2 agonist; centrally acting antihypertensive agent; decreases TPR and HR

Clonidine

13

α2 agonist; centrally acting antihypertensive agent; decreases TPR and HR;
DOC in pregnancy;
ADR: positive coombs test

Methyldopa

14

highly selective α2 agonist used to lower IOP in glaucoma

Brimonidine

15

Displaces endogeous catecholamines from vesicles, weak inhibitor of MAO, blocks catecholamine reuptake

Amphetamine

16

used to treat ADHD, analogue of amphetamine

Methylphenidate

17

Found in fermented foods; degraded by liver MAO-A; displaces the mobile pool

Tyramine

18

stimulates α and beta receptors and releases NE;
poor substrate for COMT and MAO, use is declining

Ephedrine

19

component of many decongestant mixtures; enantiomer of ephedrine

Pseudoephedrine

20

Nonselective α antagonist; noncompetitive inhibitor;
DOC for Rx of pheochromocytoma

Phenoxybenzamine

21

Nonselective α antagonist; competitive inhibitor;
Dx of pheochromocytoma

Phentolamine

22

Selective α1 antagonist; useful in the treatment of hypertension, no reflex tachycardia, shows a favorable effect on plasma lipids;
ADR : orthostatic hypertension

Prazosin

23

Selective α1 antagonist; approved for HTN and BPH;
ADR: orthostatic hypertension

Terazosin
Doxazosin

24

Selective α1 antagonist; Approved for BPH, little affect on blood pressure;
ADR: orthostatic hypertension

Tamsulosin

25

α2 receptor blocker; leads to increased release of NE

Yohimbine

26

Non-selective β blocker; sedative side effects

Propranolol

27

non-selective β blocker; long duration of action

Nadolol

28

non-selective β blocker; particularly useful in the treatment of open-angle glaucoma

Timolol

29

elective β1 adrenergic antagonist; useful for HTN

Atenolol
Metoprolol

30

selective β1 adrenergic antagonist; very-short acting

Esmolol