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Question 1

1

Direct acting adrenergic agonist; effects differ at high and low doses; causes hyperglycemia; used in anesthetics,

Answer

Epinephrine

Question 2

2

Vasoconstriction including at kidney (α-1);
Both systolic and diastolic blood pressure increase, leading to a vagal mediated reflex bradycardia

Answer

Norepinephrine

Question 3

3

Direct acting adrenergic agonist --- at low concentrations;
1 receptor leads to vasodilation --- at higher concentrations a positive inotropic effect on the myocardium is seen (beta-1)

Dopamine

Answer

Fenoldopam

Answer

Isoproterenol

Answer

Dobutamine

Answer

Terbutaline

Answer

Salmeterol

Answer

Formoterol

Answer

Phenyleprine

Answer

Methyldopa

Answer

Brimonidine

Answer

Amphetamine

Answer

Methylphenidate

Answer

Pseudoephedrine

Answer

Phenoxybenzamine

Answer

Phentolamine

Answer

Terazosin
Doxazosin

Answer

Tamsulosin

Answer

Propranolol

Answer

Atenolol
Metoprolol

Question 4

4

selective D1 agonist

Question 5

5

Non-selective β-adrenergic agonist;
β1 -> increase in HR;
β2 -> vasodilation of skeletal muscles, alleviates acute attacks of asthma

Question 6

6

Selective β1-adrenergice agonist administered as a racemic mixture;
used to increase cardiac output in acute management of HF

Question 7

7

β2-selective adrenergic agonist; contains a resorcinol ring so is not a substrate for COMT -> long acting;
USES: reduce uterine contractions in premature labor

Question 8

8

β2-selective adrenergic agonist;
USES: inhalant to relieve bronchospasm

Albuterol

Question 9

9

β2-selective adrenergic agonist;
USES: inhalant to relieve bronchospasm with a long duration of action (12 hours)

Question 10

10

β2-selective adrenergic agonist;
USES: inhalant to relieve bronchospasm with a long duration of action (12 hours)

Question 11

11

α1-selective adrenergic agonist; no direct effect on the heart, but induces reflex bradycardia when given parenterally; USES: nasal decongestant

Question 12

12

α2 agonist; centrally acting antihypertensive agent; decreases TPR and HR

Clonidine

Question 13

13

α2 agonist; centrally acting antihypertensive agent; decreases TPR and HR;
DOC in pregnancy;
ADR: positive coombs test

Question 14

14

highly selective α2 agonist used to lower IOP in glaucoma

Question 15

15

Displaces endogeous catecholamines from vesicles, weak inhibitor of MAO, blocks catecholamine reuptake

Question 16

16

used to treat ADHD, analogue of amphetamine

Question 17

17

Found in fermented foods; degraded by liver MAO-A; displaces the mobile pool

Tyramine

Question 18

18

stimulates α and beta receptors and releases NE;
poor substrate for COMT and MAO, use is declining

Ephedrine

Question 19

19

component of many decongestant mixtures; enantiomer of ephedrine

Question 20

20

Nonselective α antagonist; noncompetitive inhibitor;
DOC for Rx of pheochromocytoma

Question 21

21

Nonselective α antagonist; competitive inhibitor;
Dx of pheochromocytoma

Question 22

22

Selective α1 antagonist; useful in the treatment of hypertension, no reflex tachycardia, shows a favorable effect on plasma lipids;
ADR : orthostatic hypertension

Prazosin

Question 23

23

Selective α1 antagonist; approved for HTN and BPH;
ADR: orthostatic hypertension

Question 24

24

Selective α1 antagonist; Approved for BPH, little affect on blood pressure;
ADR: orthostatic hypertension

Question 25

25

α2 receptor blocker; leads to increased release of NE

Yohimbine

Question 26

26

Non-selective β blocker; sedative side effects

Question 27

27

non-selective β blocker; long duration of action

Nadolol

Question 28

28

non-selective β blocker; particularly useful in the treatment of open-angle glaucoma

Timolol

Question 29

29

elective β1 adrenergic antagonist; useful for HTN

Question 30

30

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Direct acting adrenergic agonist; effects differ at high and low doses; causes hyperglycemia; used in anesthetics,

Epinephrine

Vasoconstriction including at kidney (α-1);Both systolic and diastolic blood pressure increase, leading to a vagal mediated reflex bradycardia

Norepinephrine

Direct acting adrenergic agonist --- at low concentrations;1 receptor leads to vasodilation --- at higher concentrations a positive inotropic effect on the myocardium is seen (beta-1)

Dopamine

selective D1 agonist

Fenoldopam

Non-selective β-adrenergic agonist;β1 -> increase in HR; β2 -> vasodilation of skeletal muscles, alleviates acute attacks of asthma

Isoproterenol

Selective β1-adrenergice agonist administered as a racemic mixture;used to increase cardiac output in acute management of HF

Dobutamine

β2-selective adrenergic agonist; contains a resorcinol ring so is not a substrate for COMT -> long acting; USES: reduce uterine contractions in premature labor

Terbutaline

β2-selective adrenergic agonist; USES: inhalant to relieve bronchospasm

Albuterol

β2-selective adrenergic agonist; USES: inhalant to relieve bronchospasm with a long duration of action (12 hours)

Salmeterol

β2-selective adrenergic agonist;USES: inhalant to relieve bronchospasm with a long duration of action (12 hours)

Formoterol

α1-selective adrenergic agonist; no direct effect on the heart, but induces reflex bradycardia when given parenterally; USES: nasal decongestant

Phenyleprine

α2 agonist; centrally acting antihypertensive agent; decreases TPR and HR

Clonidine

α2 agonist; centrally acting antihypertensive agent; decreases TPR and HR; DOC in pregnancy; ADR: positive coombs test

Methyldopa

highly selective α2 agonist used to lower IOP in glaucoma

Brimonidine

Displaces endogeous catecholamines from vesicles, weak inhibitor of MAO, blocks catecholamine reuptake

Amphetamine

used to treat ADHD, analogue of amphetamine

Methylphenidate

Found in fermented foods; degraded by liver MAO-A; displaces the mobile pool

Tyramine

stimulates α and beta receptors and releases NE;poor substrate for COMT and MAO, use is declining

Ephedrine

component of many decongestant mixtures; enantiomer of ephedrine

Pseudoephedrine

Nonselective α antagonist; noncompetitive inhibitor; DOC for Rx of pheochromocytoma

Phenoxybenzamine

Nonselective α antagonist; competitive inhibitor; Dx of pheochromocytoma

Phentolamine

Selective α1 antagonist; useful in the treatment of hypertension, no reflex tachycardia, shows a favorable effect on plasma lipids; ADR : orthostatic hypertension

Prazosin

Selective α1 antagonist; approved for HTN and BPH; ADR: orthostatic hypertension

TerazosinDoxazosin

Selective α1 antagonist; Approved for BPH, little affect on blood pressure; ADR: orthostatic hypertension

Tamsulosin

α2 receptor blocker; leads to increased release of NE

Yohimbine

Non-selective β blocker; sedative side effects

Propranolol

non-selective β blocker; long duration of action

Nadolol

non-selective β blocker; particularly useful in the treatment of open-angle glaucoma

Timolol

elective β1 adrenergic antagonist; useful for HTN

AtenololMetoprolol

selective β1 adrenergic antagonist; very-short acting

Esmolol

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Vasoconstriction including at kidney (α-1);
Both systolic and diastolic blood pressure increase, leading to a vagal mediated reflex bradycardia

Direct acting adrenergic agonist --- at low concentrations;
1 receptor leads to vasodilation --- at higher concentrations a positive inotropic effect on the myocardium is seen (beta-1)

Non-selective β-adrenergic agonist;
β1 -> increase in HR;
β2 -> vasodilation of skeletal muscles, alleviates acute attacks of asthma

Selective β1-adrenergice agonist administered as a racemic mixture;
used to increase cardiac output in acute management of HF

β2-selective adrenergic agonist; contains a resorcinol ring so is not a substrate for COMT -> long acting;
USES: reduce uterine contractions in premature labor

β2-selective adrenergic agonist;
USES: inhalant to relieve bronchospasm

β2-selective adrenergic agonist;
USES: inhalant to relieve bronchospasm with a long duration of action (12 hours)

β2-selective adrenergic agonist;
USES: inhalant to relieve bronchospasm with a long duration of action (12 hours)

α2 agonist; centrally acting antihypertensive agent; decreases TPR and HR;
DOC in pregnancy;
ADR: positive coombs test

stimulates α and beta receptors and releases NE;
poor substrate for COMT and MAO, use is declining

Nonselective α antagonist; noncompetitive inhibitor;
DOC for Rx of pheochromocytoma

Nonselective α antagonist; competitive inhibitor;
Dx of pheochromocytoma

Selective α1 antagonist; useful in the treatment of hypertension, no reflex tachycardia, shows a favorable effect on plasma lipids;
ADR : orthostatic hypertension

Selective α1 antagonist; approved for HTN and BPH;
ADR: orthostatic hypertension

Terazosin
Doxazosin

Selective α1 antagonist; Approved for BPH, little affect on blood pressure;
ADR: orthostatic hypertension

Atenolol
Metoprolol