Fluids Flashcards
Discuss Hyperchloremic renal afferent arteriole effects?
Causes vasoconstriction of renal afferent arteriole
Physiology Journal: Hyperchloremia (induced by changing an intra-aortic, super-renal infusion of 1.2 M Na acetate to 1.2 M NaCl) reduced the glomerular filtration rate (GFR) by 31 +/- 3% (P less than 0.001; n = 27), and the clearance of p-aminohippurate (CPAH) by 36 +/- 4% (P less than 0.01).
HOWEVER:
2017 study in Nephrology journal shows: Hyperchloremia occurs commonly among critically ill septic patients admitted to the ICU, but does not appear to be associated with an increased risk for AKI within the first 72 h of admission.
Although not studied clinically, hyperchloremia-associated AKI may be most pronounced in states of high RAAS activity. Since Angiotensin II (ANG II) (27, 51, 73, 74, 211) and endothelin (210) have been shown to increase chloride conductance and vasoconstriction of the afferent arteriole.
