Forensic Toxicolgy and pharmacology pt2 Flashcards

(55 cards)

1
Q

Toxicology

A

a branch of biology, chemistry, and medicine (more specifically pharmacology) concerned with the study of the adverse effects of chemicals on living organisms.

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2
Q

postmortem drug testing

A

The branch of toxicology focused on the analysis of biofluids after death of the body.

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3
Q

workplace drug testing

A

A branch of toxicology focused on analysis of employee samples

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4
Q

biofluids

A

Blood, urine, bile, etc.; fluids obtained from the body

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5
Q

ADME

A

The process by which a drug moves through the body: absorption, distribution, metabolism and excretion

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6
Q

Opiates

A

A term for the class of narcotic drugs derived from the opium plant, including morphine and codeine. heroin is produced from morphine

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7
Q

depressants

A

Substance that depress the central nervous system and cause symptoms such as slowed heart rate and breathing

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8
Q

amphetamine

A

A controlled substance that, along with its analogs such as methamphetamine, creates an excitatory condition (stimulation), state of weakfulness, and euphoria

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9
Q

stimulants

A

Drugs that produce produces a temporary increase of functional activity or efficiency

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10
Q

precursors

A

Substances that can be converted into an abused substances

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11
Q

cocaine

A

A control substance derived from the erythroxylin cocoa plant that creates an excitatory condition (stimulation), state of wakefulness, and euphoria

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12
Q

cannabiboids

A

A term applied to marijuana and parts of the plant Cannabis sativa in which tetrahydrocannabinol (THC) is the active

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13
Q

Tetrahydricannabinol (THC)

A

The active ingredient in Marijuana

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14
Q

Polypharmacy

A

A mixture of drugs

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15
Q

volume of distribution

A

An equation that relates dose of a drug to blood concentration

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16
Q

Gas chromatography

A

Gas flowing through a coated tube separates compounds by their size, weight, and chemical reactivity with the coating of the cube or column

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17
Q

Cyanide

A

A highly toxic chemical, especially in the form of gas (hydorgen cyanide)

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18
Q

methemoglobin

A

An oxidized form of hemoglobin.

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19
Q

cyanomethemoglobin

A

A complex of cyanide and methemoglobin; used to treat cyanide posioning

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20
Q

carboxyhemoglobin

A

Hemoglobin in which the oxygen has been replaced by carbon monoxide (CO)

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21
Q

thin layer chromatography (TLC)

A

The use of a solvent that travels through a porous medium to separate compounds based on their chemical affinity with the solvent and the medium

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22
Q

mobile phase

A

In a chromatographic system such as thin layer chromatography or gas chromatography, the phase that moves.

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23
Q

carrier gas

A

The mobile phase in gas chromatography (GC)

24
Q

GC-MS

A

Acronym for gas chromatography coupled with mass spectrometry

24
National Institute of High Standards and Technology (NIST)
Federal agency responsible fro setting, approving, and maintaining measurements and materials standards in the United States (formerly National Bureau of Standards)
25
liquid chromatography-mass spectrometry (LC-MS)
An analytical instrument that combines a liquid chromatography with a mass spectrometer as the detect; analogous to GC-MS
26
thermolabile
A substance that breaks at elevated temperatures
27
colorimetric testing
testing in which a change or production of color is used to screen for compounds
28
tandem mass spectrometery
A detection system with more than one mass spectrometer in series
29
marsh test
first and most famous color-based test for arsenic
30
inductively coupled plasma-mass spectrometry (ICP-MS)
A form of mass spectrometry used to detect inorganic materials and metals
31
Toxicokinetics/ pharmacokinetics
The study of how genetic factors influence toxicology and drug effectiveness
32
toxicogenetics/ pharmacogenetics
The study of the genetic influences on the responses of organisms to toxins.
33
postmortem redistribution
The redistribution of drugs in the body that occurs after death
34
Controlled Substance Act (CSA)
legislation in the US that defines illegal drugs and classifies them by schedules
35
Drug Enforcement Administration (DEA)
The US government agency responsible for regulation of controlled drugs
36
Over the counter (OTC)
Medicines that can be purchased without a prescription
37
cutting agents
A substance added to an illicit drug to reduce the concentration
38
standards
analytical standards established by a consensus of the scientific community engaged in the analysis of drugs of abuse
38
American Society for Testing and Materials (ASTM)
A group of that establishes national and international standard practices fr procedures and analyses
39
SWGDRUG
Scientific Working Group for the Analysis of Seized Drugs
40
Botanical examinations
Study of various plant structure, such as roots, stems, branches, leaves, fruits, or flower, that may be used to determine time and season of death as well as possible prior location of remains
41
macroscopic examinations
Visual examination generally performed with the unaided eye; used to identify class characteristics
42
cystolithic (bear-claw shaped) hairs
hairs on the surface of a leaf/ finer clothing
43
Duquenois-Levine
Chemical color test used to confirm the presence of cannabinoids in plant material
44
hashish
The resin from marijuana that has been isolated from the plant material
45
mescaline
A hallucinogen found in cactus buttons
46
alkaloids
Substance formed by in the plant tissues and in the bodies of animals. Morphine and codeine are alkaloids of opium
47
psilocin
a substituted tryptamine alkaloid and a serotonergic psychedelic substance
48
psilocybin
a naturally occurring psychedelic compound produced by more than 200 species of mushrooms, collectively known as psilocybin mushrooms
49
wet chemical procedures
Procedure that involve solvents, extractions, etc.; not instruments
50
microcrystaline tests
A reaction between the compound of interest and chemical reagent that results in the formation of unique crystals that can be observed with the micrscope
51
extractions/ liquid extraction
Separation of the compound of interest from the rest of the samples
52
infrared spectroscopy
Use of the absorption of infrared radiation to produce a chemical fingerprint of a substances; also referred to as IR spectroscopy
53
clandestine drug laboratories
Illicit location that manufactures controlled