Formula stuff

Question 1

Which weight do you use for all drugs when dosing if they are underweight?

Answer 1

Total body weight (TBW)

Question 2

Which weight do you use for most drugs if they are normal weight or obese?

Answer 2

TBW

Question 3

Which drugs do you use IBW for if they are normal or obese weight? What about AdjBW if they are obese what drug class?

Answer 3

IBW: Acyclovir, synthroid, aminophylline

AdjBW: Aminoglycosides

Question 4

When weight is >20kg what is the formula for fluid needs?

Answer 4

1500mL + 20mL(weight in kg - 20)

Question 5

What is 1 grain equal to

Answer 5

65 mg

Question 6

what is specific gravity

Answer 6

g/mL

Question 7

What is the normal ABG pH?

Answer 7

7.35-7.45

Question 8

What defines respiratory and metabolic acid/alkolosis with pCO2 and HCO3?

Answer 8

Respiratory: pCO2 <35 alkalosis, pCO2 >45 acidosis

Metabolic: HCO3 > 26 alkalosis, HCO3 < 22 acidosis

Question 9

How to calc anion gap?

Answer 9

Na - Cl - HCO3

Question 10

ANC calculation

Answer 10

WBC x (%segs + % bands)/100

Question 11

Risk equation

Answer 11

Risk = # of subjects in group with unfavorable event/ total # of subjects in group

Question 12

Relative risk and RRR and ARR

Answer 12

RR= risk in treatment group/ risk in control group

RRR= (% risk in control group - % risk in treatment group) / % risk in control group

ARR= (% risk in control group - % risk in treatment group)

Question 13

NNT

Answer 13

1/ARR as a decimal

Question 14

Insulin to carb ratio for rapid acting

Answer 14

Rule of 500 for rapid acting insulin

500/TDD (total daily dose) = grams of carbs covered by 1 unit of rapid acting

Question 15

Insulin to carb ratio for regular insulin

Answer 15

rule of 450

450/TDD= grams of carbs covered by 1 unit of reglular

Question 16

Correction factor for rapid insulin and for regular insulin

Answer 16

Rapid: 1800/TDD= CF for 1 unit of rapid acting insulin

Regular: 1500/TDD= CF for 1 unit of regular

Question 17

Correction Dose for insulin

Answer 17

CD= (BG now - BG target) / CF

Question 18

Friedewald equation

Answer 18

LDL = TC - HDL - TG/5

Not valid when TG > 400

Question 19

Minimum weighable quantity (MWQ)

Answer 19

Sensitivy requirement / 0.05 = MWQ

Question 20

BSA

Answer 20

BSA= square root of [ Ht (cm) x Wt (kg) / 3600 ]

Question 21

Bioavailability

Answer 21

F(%) = 100 x AUCextra / AUCintra x DOSEintra / DOSEextra

extravascular and intravascular

Question 22

Volume of distribution

Answer 22

VD = Amount of drug in body / concentration of drug in plasma

Question 23

Clearance

Answer 23

Cl = (F x Dose)/AUC

or

Cl=ke x Vd

Question 24

Elimination rate constant

Answer 24

ke = Cl/Vd

Question 25

Loading dose

Answer 25

LD = (Desired concentration x Vd) / F

Question 26

Phenytoin total correction for albumin

Answer 26

albumin < 3.5 Phenytoin corrected (mcg/mL) = Total phenytoin measured / (0.2 x albumin) + 0.1 Can also do for valproic acid

Question 27

KCl solution (oral) to tablets conversion KCl 10% is what tablets

Answer 27

KCl 10% = 20 mEq/15 mL

Question 28

Calcium salts what % elemental calcium Carb and citrate

Answer 28

carbonate 40% Citrate 21%

Question 29

Aminophylline to Theophylline conversion

Answer 29

ATM (amin to theo multiple) Amino to Theo x 0.8 so theo is stronger

Question 30

Loop diuretic potency

Answer 30

Furosemide 40mg Torsemide 20mg Bumetanide 1 mg All are 1:1 IV: PO except furosemide is 1:2 so double PO dose from IV

Question 31

Metoprolol IV:PO conversion

Answer 31

1:2.5 IV:PO

Question 32

Iron elemental % Ferrous sulfate

Answer 32

20% elemental iron so 325mg x 0.2 has 65 mg iron

Question 33

Insulin NPH dosed BID -> glargine dosed daily what is conversion? Toujeo -> Lantus or Basaglar

Answer 33

NPH BID -> glargine QD (use 80% of NPH dose) Toujeo -> Lantus/Basaglar (use 80% Toujeo dose)

Question 34

synthroid IV:PO dose conversion

Answer 34

IV:PO 0.75:1

Question 35

Steroid potency and equivalence

Answer 35

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Question 36

Statin equivalence

Answer 36

Pharmacists Rock At Saving Lives and Preventing Fatty-deposits Pitavastatin 2mg Lovastatin 40mg Rosuvastatin 5mg Pravastatin 40mg Atorvastatin 10mg Fluvastatin 80mg Simvastatin 20mg

Question 37

Lithium conversions between syrup, mg, and mEq

Answer 37

5 mL = 300mg = 8 mEq