Formulations for Analgesia - Extended Release and Dosage Forms Flashcards Preview

#B32PAI Pharmaceutics > Formulations for Analgesia - Extended Release and Dosage Forms > Flashcards

Flashcards in Formulations for Analgesia - Extended Release and Dosage Forms Deck (7)
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1

What are the two types of extended release and why are they used?

1. Prompt achievement of plasma concentration of drug remains constant value within therapeutic range for a satisfactory amount of time
2. Prompt achievement of plasma concentration of drug and declines at a slow rate within the therapaeutic range

2

What are sublingual tablets?

Transmucosal delivery in oral cavity
Small/porous fast disintegrating tablet placed under tongue

3

What are dispersible tablets and why are they used?

Useful in patients with difficulty swallowing
Dropped into a glass of water, CO2 liberated
-reaction of carbonate/bicarbonate with a weak acid such as citric acid

Fast disintegration and dissolution of the drug
Buffered water increases the pH of the stomach so faster emptying /shorter residence so reaches the small intestine quicker (main site of absorption)

4

What are suspensions?

Drug in solid phase (powder) suspending in a liquid formulation
A solid in liquid colloid us called a suspension

5

When are suspensions used?

Often in children
Antacids, antibiotics, antifungals, analgesics

6

How can suspensions become unstable?

Flocculation, aggregation (reversible)
Sedimentation and Ostwald ripening

7

What are fast dissolving oral delivery systems?

Solid dosage forms that dissolve rapidly in the oral cavity that results in solution or suspension (no need for water)
Dissolves and disperses in saliva
Potential for increased absorption as portion of drug may be absorbed in mouth, pharynx or oesophagus