Foundation 2

Question 1

Drugs most associated with severe cutaneous adverse reactions:

SJS (Stevens Johnson syndrome)

TEN (toxic epidermal necrolysis)

DRESS (drug reaction with eosinophilia and systemic symptoms)

Answer 1

Allopurinol
Amoxicillin
Ampicillin
Carbamazepine
Ethosuximide
Lamotrigine
Nevirapine
Phenytoin
Sulfa
Sulfasalazine
Vancomycin

Others:
Amiodarone
Etravirine
Fosphenytoin
Isoniazid
Macrolides
Minocycline
Olanzapine
Oxcarbamazepine
Phenobarbital
Piroxicam
Quinine
Quinolones
Rifampin
Terbinafine

Question 2

Sulfa drugs

Answer 2

Thiazide diuretics
Loop diuretics, except ethacrynic acid
Sulfonylureas
Acetazolamide
Zonisamide
Celecoxib
Darunavir
Sulfasalazine
Sulfadiazine
Sulfamethoxazole

Question 3

Drugs most associated with photosensitivity

Answer 3

Amiodarone
Diuretics (thiazide & loop)
MTX
Oral and topical retinoids
Quinolones
St. John’s wort
Sulfa drugs
Tacrolimus
Tetracycline
Voriconazole

Others:
Antihistamine 1st Gen
Chloroquine
Coal Tar
Fluorouracil
Griseofulvin
NSAIDs
Quinidine
Tigecycline