Fresh vs Old blood

Question 1

TRANSFUSE-2017

Answer 1

Question-
does the transfusion of the freshest available red cells compared to standard care impact on patient mortality

Results:
*No difference in 90 day mortality in the two groups
*Patients with short-term storage blood - more febrile non-haemolytic transfusion reactions
*Patients who had short-term storage blood with greater than median APACHE III risk of death had increased mortality

Question 2

ABLE-2015

Answer 2

ICU patients, anticipated length of MV- >48hrs
Fresh <8days v/s standard issue RBC(2-42days) -does it reduce mortality

No diff in 90 day mortality or other secondary outcomes