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Flashcards in From Boron and web notes Deck (18)
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3 actions of SNS in the kidney

- vasoconstriction of afferent arteriole
- enhance Na reabsorption in PCT
- increases renin secretion by stimulating granular cells of afferent arteriole

1

where does metabolism of vitamin D occur in the kidney

3rd hydroxylation occurs in the proximal tubule

2

what is the action of active metabolite of vitamin D

controls calcium and phosphate metabolism by acting on intestines, kidneys and bone

3

when is EPO secreted from the kidney

in response to fall in local tissue pO2

4

which prostaglandin does the kidney secrete

prostacyclin

5

urine clearance equations (in words)

the conc of substance in urine x urine flow / plasma conc of substance

6

normal glomerular filtration rate

180L/day or 125ml/min

7

what is autoregulation in the kidney

when high renal artery pressure there is a proportional increase in the resistance of the afferent arterioles
(caused by the myogenic response and TGF)

8

what is the role of the macula densa in Tubuloglomerular feedback

senses increased Na and Cl due to increased flow through the kidney and therefore increased GFR. Releases particularly ATP, adenosine and thromboxane to act on the afferent arteriole to constrict --> decreasing GFR

9

what is the action of angiotensin II on the:
- afferent arteriole
- efferent arteriole
- TGF mechanism

afferent - constriction
efferent - constriction
TGF - increased sensitivity

10

how is urea made

generated from end product of amino acid catabolsim NH4+ in the liver

11

normal reabsorption of phosphate

PT absorbs 80%
DT absorbs 10%
(excrete 10%)

12

how is phosphate reabsorbed

mostly by transcellular route
some through active transport coupled with Na

13

action of PTH on phosphate and calcium reabsorption

inhibits phosphate reabsorption --> promoting excretion
promotes calcium reabsorption --> decreasing excretion

14

what is the most conc urine that we can produce? and what is the minimum volume of urine that this can be dissolved in

1200mOsm - minimum of 500mL per day

15

how much of the CO is at the kidneys

20%

16

where is the SNS supply greatest? to the afferent or efferent arteriole

afferent

17

what is the result of SNS stimulation on the kidney

raises BP by vasoconstriction of the whole body arterioles and by decreasing GFR by vasoconstriction of afferent arterioles (and therefore decreased Na and H20 excretion --> maintaining BV and therefore BP)