Flashcards in From Firecracker Deck (34):
hemorrhagic adrenalitis from fulminant meningiococcemia (N. meningitis sepsis)
Autosomal dominant excess loss of potassium and reabsorption of sodium. HTN, Meta alkalosis. treat with amilioride (potassium sparing).
Apple green birefringence
Amyloidosis (Congo Red stain under polarized light)
Most common inherited aplastic anemia, defects in non-homologous end-joining
Naegleria fowleri causes...?
primary amoebic meningoencephalitis
Acanthamoeba spp. causes...?
granulomatous amoebic encephalitis, most common in immunocompromised individuals (HIV)
Type 1 RTA
DCT failure to secret H and resorb K. a-intercalated cells.
Collagen IV attack in lung and renal. type II hypersensitivity, IgG anti-GBM (against type IV collagen), attack glomeruli and alveoli, C3 positive in GBM, ANCA-negative.
scopolamine toxic side effects
mydriasis, cycloplegia, CNS anticholinergic toxidrome. It is an antimuscarinic like atropine.
4 drugs to treat CMV
ganciclovir, valganciclovir, foscarnet, cidofovir
Insufficient resorption of tryptophan. Autosomal recessive. Treat with high-protein diet + nicotinic acid. Symptoms of pellagra: Diarrhea, Demetia, Dermatitis. Neutral aminoaciduria.
Kimmelstiel-Wilson nodules pathomneonic for...?
Bilateral renal agenesis
Failure of fetal renal excretion
Oligohydramnios, resulting in decreased amniotic fluid
Multiple anomalies (Potter phenotype) and early death
B1 blockers on the kidney?
Reduce renin release, thereby reducing angiotensin II, causing vasodilation
Hodgkin's lymphoma. These are bi-nucleated "owl eye" B cells. Necessary but not sufficient for diagnosis. Can release cytokines which cause minimal change disease.
defective collagen IV assembly. Ocular (lens and cornea), nephritic, hearing loss. Basketweave GBM, red cell casts.
Prodrug, sulfated by liver, causes vasodilation
Furosemide (Lasix) toxicity mnemonic
Poor brain development
Enlarged fontanelle, delayed dentition, retarded bone age
Very long chain fatty acid buildup in CNS, adrenals, and testes. X-linked, presents in young men.
Used in young kids to treat: Ewing sarcoma, Rhabdomyosarcoma, and Wilms
iron chelator used to prevent cardiotoxicity from doxorubicin or daunorubucin
3rd and 4th pharyngeal pouch failure. Congenital t-cell deficiency, cleft palate, often fatal cardiac defects. No thymus or parathyroid glands, hypocalcemic. 22q11.2
4 types of thyroid carcinoma
Autosomal recessive, defect in Na/K/Cl cotransporter in thick ascending limb, causes salt and water wasting
San Joaquin Valley Fever
Coccidiomycosis -- "desert rheumatism"
pufferfish venom, Na channel blocker
genetic disorder of cardiac Na channels, ventricular tachyarrhythmias and sudden cardiac death. Autosomal dominant, Asian males. St elevation, negative T-wave. Treat with an implanted defibrillator.
Fitz-Hugh Curtis syndrome
perihepatitis, infection of the liver capsule and peritoneal surfaces of the anterior right upper quadrant from Neisseria and Chlamydia spp. Acute symptoms manifest as a patchy purulent and fibrinous exudate known as “violin string” adhesions.
Topoisomerase II and IV. Enters via porins.
Lupus affiliated drugs
SHIPP-E: Sulfa drugs, Hydralazine, Isoniazid, Procainamide, Phenytoin, Etanercept