From Quizlet

Question 1

Limit MCT oil to __ mL/day

Answer 1

100 mL/day (6.5 tbsp or 760 kcal)

Question 2

macrobiotic diet does not include

Answer 2

mango pineapple and papaya

Question 3

zoledronic acid (zometa) is used for what

Answer 3

bone mets

Question 4

zoledronic acid should be given with what vitamins

Answer 4

500 mg calcium, 400 IU vit D

Question 5

St Johns Wort increases/decreases activity of vinblastine (velban) and vincristine (oncovin)

Answer 5

decreases by inducing cyt P4503A4 (CYP3a4): found in liver and intestine oxidizes xenobiotics like toxins or drugs to they can be removed from the body

Question 6

grapefruit juice can increase a drugs activity by inhibiting enzyme responsible for drugs metabolism. what is one example of this

Answer 6

grapefruit juice and docetaxel resulted in reduced clearance by 15%

Question 7

3-4 foods that can alter CYP3a4 (and thus alters drugs efficacy/toxicity)

Answer 7

pomegranate, grapefruit, star fruit, seville oranges citrus juicecs

Question 8

5 supplements that affect Cyp3a enzymes

Answer 8

St Johns Wort, Black cohosh, ginseng, gingo bilboa, goldenseal

Question 9

which drug causes pharyngolaryngeal dysesthesia

Answer 9

(cold feeling) oxaliplatin (eloxatin)

Question 10

high vomiting chemos

Answer 10

cyclophosphamide H, doxorubicin M, cisplatin H, ifosfamide M, mechlorethamine H, carmustine H dacarbazine H

Question 11

streptozotocin (zanosar) can alter what metabolism

Answer 11

glucose- hypoglycemia

Question 12

what should women not take within 2 hrs of tamoxifin

Answer 12

antacids

Question 13

on EN hyponatremia may be caused by overhydration, GI sodium losses and what

Answer 13

SIADH

Question 14

2 types of targeted therapy

Answer 14

monoclonal antibodies, small-molucule drugs (end in mab)

• these work by targeting proteins or genes the help stop cancer from growing or spreading

Question 15

leucovorin (reduced form of folic acid) is given to decrease side effects of methotrexate but is also given with fluorouracil which does what

Answer 15

makes side effects more severe

Question 16

what drug is used as an antidote for chemotherapy

Answer 16

uridine triacetate (vistogard)

Question 17

cytokines

Answer 17

protein mediators produced by inflammatory cells which signal metabolic changes

• those related to cancer cachexia = cachectic, TNF, interleukin 1,6, interferon

Question 18

tumor necrosis factor

Answer 18

hormone like protein that releases fat from fat stores reduces the concentration of enzymes required for the production and storage of fat and induces stage of anorexia

Question 19

veno-occlusive disease

Answer 19

is sinusoidal obstruction system

Question 20

macrobiotic diet

Answer 20

no nightshade veggies (avoid animal products and dairy -processed food)

Question 21

to decrease acute vomiting (within 24 hours of chemo) these 3 drugs are often given before chemo

Answer 21

ondansetron (serotonin receptor agonist), dexamethasone (steroid), aprepitant (NK1 receptor agonost)

Question 22

5ht3 receptor agonist

Answer 22

ondansetron

Question 23

anticipatory n/v can be helped with

Answer 23

ativan

Question 24

T/F mucositis is just inflammation of mouth and esophagus

Answer 24

F inflammation of mucous membrane lining of GI tract (mouth to butthole)

Question 25

which chemo causes damage to GI tract

Answer 25

5-FU and methotrexate

Question 26

steroid side effects

Answer 26

osteoporosis, fluid retention, adrenal suppression, glucose intolerance, lyte imbalance, muscle wasting

Question 27

when boney mets for breast lung and pancreases occur hypercalemia can also occur, should you reduce calcium in diet?

Answer 27

no

Question 28

energy needs for children HCT

Answer 28

initial: 1.6-1.8 x BMR and maintenance 1.4-1.6 x BMR

Question 29

how many mL of MCT should someone start with

Answer 29

15mL (no more than 20 mL at a time)

Question 30

Physical activity most proven in which cancers

Answer 30

Breast colon endometrial and lung

Question 31

Serum magnesium can drop with which chemos

Answer 31

Cyclosporine, oxaliplatin, cetuximab, panitumab

Question 32

Pet scan

Answer 32

Radioactive glucose

Question 33

Indirect calorimetry measures what

Answer 33

RMR

Question 34

HCT kcal needs for adults

Answer 34

30-35

Question 35

Pro for cancer , hct , short bowel , IBD

Answer 35

1.0-1.5, 1.5, 1.5-2.0, 1.0-1.5

Question 36

SIADH can cause what nutrition related

Answer 36

Over hydration

Question 37

RDa for vit

Answer 37

``` Calc 1000-1200 - 2500 Iron 8, 18 - 45 Phos 700 - 4000 Zinc 11 and 8 - 40 Vit A 900-700 -2800 Folate 400 -1000 B12 2.4 - Vit C 90 and 75 - 2000 Vit D 15 and 20 - 100 Vit E 15 - 1000 ```

Question 38

Mnt for thrombocytopenia

Answer 38

Overly rough or course foods to avoid cut bleeding

Question 39

Anemia

Answer 39

Many reasons but some could be iron folate and b12 deficiency

Question 40

Anemia labs what do they mean Hgb ``` Serum ferritin Serum iron tibc Transferrin sat RDW MCV ```

Answer 40

Hgb says if there is anemia < 8 very high ``` Iron deficiency Low serum ferritin Low serum iron High TIBC Low transferrin High RDW Low MCV ``` ``` B12 deficiency High MCV Low serum b12 High serum mma High hcy (also b6) ``` Folate deficiency High MCV Low B12 Low rbc and serum folate (fluctuate with oral intake)

Question 41

What could potentially help with PN in HCT

Answer 41

Glutamine .2-.5 g/kg/day

Question 42

HCT how much fat

Answer 42

25-30% of kcal

Question 43

Potentially beneficial supplements for peripheral neuropathy

Answer 43

Vit E, calcium, mg, glutamine, glutathione, acetyl L carnitine

Question 44

EPA is useful for malnutrition how much

Answer 44

.26-6.0 g per day no pancreas

Question 45

Head and neck cancer which vitamin could increase cancer risk again

Answer 45

Vit e more than 400 iu

Question 46

Improve taste with what vit

Answer 46

50 mg elemental zinc less than 60 days

Question 47

What nectar can help with thickened saliva

Answer 47

Papaya