Fructose, Galactose, Lactose Flashcards Preview

Biochemistry > Fructose, Galactose, Lactose > Flashcards

Flashcards in Fructose, Galactose, Lactose Deck (11):
1

Essential fructosuria enzyme? What are the symptoms? Why is asymptomatic and benign?

Enzyme: fructokinase

Symptoms: fructose in urine and blood

Because fructose does not get trapped in the cells

2

Fructose intolerance enzyme? What is the difference between essential fructosuria and fructose intolerance? What is inhibited because of the enzyme def.? Why is it inhibited?

Enzyme: Aldolase B

Fructose is phosphorylated in Aldolase B def.

Gluconeogenesis and Glycogenlysis

Phosphate is decreased

3

Symptoms of Fructose intolerance will come up when you ingest what kinds of food? What will show up in the urine and will the urine show glucose?

Honey, juice, fruit

reduced sugars
No

4

Symptoms of Fructose intolerance?

Hygoglycemia, jaundice, cirrhosis, vomiting

5

Galactokinase def. enzyme? If galactose is present in the diet, what will accumulate? Symptoms?

Galactokinase

Galactitol

Failure to track objects or develop social smile

6

Classic galactosemia enzyme? How does this enzyme def. cause damage to organs like the lens?

galactose-1-phosphate uridyltransferase

"Classic 11"

toxic substances accumulate in the lens

7

Symptoms of galactosemia? In neonates, this can lead to what kind of sepsis? What two sugars do you have to exclude for these patients?

Cataracts, hepatosplenomegaly, intellectual disability, failure to thrive.

E.coli

galactose and lactose

"Fructose is to Aldolase B as Galactose is to UridylTransferase (FAB GUT)"

8

Classic Galactosemia and Fructose intolerance can lead to a depletion of?

phosphate

9

In what organs do you only have aldose reductase?

Lens, Schwann cells, retina, kidney.

10

Lactase is what kind of enzyme? How does gastroenteritis and autoimmune disease cause lactose intolerance? What bug can cause gastroenteritis?

brush border

Loss of brush border

Rotavirus

11

What will stool show in a patient with lactose def. (2 things)? What about a mucosal biopsy?

decreased pH and and increased H+ breathe (increased acid)

Normal mucosa