FTLD

Question 1

types of FTL degeneration?

Answer 1

frontotemporal dementia (Pick’s disease)
progressive non fluent aphasia CPA
semantic dementia

Question 2

common features of frontotemporal lobe dementia?

Answer 2

onset before 65
insidious onset
relatively preserved memory and visuospatial skillS
personality change and social conduct problem

disinhibition, increased appetitie, preservation behaviours, hyperorality

Question 3

macroscopic and microscopic changes in Picks disease?

Answer 3

atrophy of frontal and temporal lobes, pick bodies (spherical aggregation of tau), gliosis, neurofibrillary tangles, senile plaques

Question 4

what should not be used in FTLD?

Answer 4

AChE inhibitors or memantine

Question 5

difference in semantic and CPA?

Answer 5

in semantic they are fluent but empty or little meaning . Memory is better in semantic for recent event than remote unlike Alzheimers