Function Flashcards by Katie Tuttle

Q

DP Phenotype SLAP1 OT-1

A

More DP bright cells 63% Fewer DP dull cells - 33%

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Q

DP expression of OT-1 Transgene (SLAP1-/-)

A

WT DP TCR high cells express much higher levels of the transgene (compared to WT TCR low, fold change) than the DP bright SLAP1-/- OT1 cells

CD5 expression is higher on the SLAP1-/- OT1 cells.

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Q

Thymic subset phenotype in OT1

A

More DP bright, fewer DP dull and fewer total CD8+ cells

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