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Flashcards in fundamentals of pharmacology Deck (16):
1

pharmacodynamics =

what the drug does to the body - the mechanisms of action

2

pharmokinetics =

what the body does to the drug, how its absorbed, distributed and metabolised etc.

3

clinical uses =

what the drug can be used for

4

what is a drug

any chemical that has a biological effect

5

what are the characteristics of drugs (3)

1) drugs have a variety of effects/tissue sensitivity
2) drugs are potent - act in low concentrations due to receptors being able to amplify signals
3) chemical sensitivity (enantiomer + for adrenaline is 100 times more effective than the enantiomer -)

6

what are the general properties of receptors (3)

expressed in different tissues
amplify signals
highly selective targets

7

what is the definition of a receptor

a specific target molecule with which a drug interacts with to produce a cellular response

8

agonist =

a drug which binds to a recptor to produce a biological cellular response

9

antagonist =

drug that binds to a receptor but produces no biological response

10

what does atenolol do

it blocks adrenaline mediated increase in heart rate

11

what are the two steps in drug action

occupation (drug binding to receptor) - affinity
activation (producing a response) - efficacy

12

what do agonists have

affinity and efficacy

13

what do antagonists have

they have affinity but no efficacy

14

what are the two main ways of classifying drugs

according to clinical use
according to target receptors

15

what is prazosin

alpha 1 antagonist (decrease blood vessel contraction)
NA > A > Iso

16

beta adrenoceptors

Iso > A > NA