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Flashcards in receptor mechanisms Deck (15):
1

what do indogenous neurotransmitters/ hormone do

they occupy a receptor (affinity) and cause a biological response (efficacy) - (like a lock and key)

2

an exogenous agonist

will be different in shape slightly but will mimic the indogenous response

3

an antagonist

will stop the indogenous from binding by occupying the receptor (affinity) but causes no response (no efficacy)

4

what are the four superfamilies of receptors

ligand gated ion channels (fast)
G protein coupled receptors (slow)
Tyrosine kinase linked
Nuclear receptors

5

what is the difference between ANS neurones and somatic NS

ANS has neurones that are in series, synapsed at the ganglia

6

what can ANS initiate

both fast and slow responses

7

what type of receptors are nicotinic receptors

ligand gated ion channels (fast)

8

what type of receptors are Muscurinic receptors

G protein coupled receptors

9

how many transmembrane domains and proteins do nicotinic receptors have

4 transmembrane domains - TMD2 which as deep groove
5 proteins

10

what proteins are nACH muscle receptors made from

two alpha proteins
one beta proteins
one gamma protein
one delta / epsilon in embryos

11

what proteins are nACH in nerves made from

alpha proteins
beta proteins

12

what does binding of Ach result in

an excretory junction potential (influx of cations)

13

what do inhibitory ligand gated ion channels do

allow anions to enter

14

how many subunits does GABAa have

alpha, beta and gamma subunit (with 6 subtypes of each)

15

what units do benzodiazepines bind to

Gamma