Fungal Meningits, Poliovirus, Polyoma Virus Flashcards Preview

Neuro Block 2 > Fungal Meningits, Poliovirus, Polyoma Virus > Flashcards

Flashcards in Fungal Meningits, Poliovirus, Polyoma Virus Deck (30):
1

How do fungi get into CSF

from blood

2

treatment for fungal meningitis

amp B and flucytosine

3

cryptococcosis neoformans is transmitted by?

inhaled pigeon droppings

4

85% of pts with cryptococcosis neoformans infections have what underlying condition?

HIV

5

structure of cryptococcosis neoformans

encapsulated yeasts
**capsule is polysacchairde and anti-phagocytotic

6

initial pres of cryptococcosis neoformans CNS infection

asympomatic pulm infection

7

how is cryptococcosis neoformans CNS infection diagnosied?

yeasts with halos on india ink from CSF of pt

8

fungal agent responsible for steriod outbreak

Exserohilum rostratum
= environmentala black mold

9

structure of poliovirus

non-enveloped, icosahedral + RNA

10

how is polio tranmitted

fecal- oral route

11

reservior for poliovirus

humans

12

where in the body does poliovirus replicate once infected

lymphoid tissue of pharynx and gut (virus detected in throat and feces) --> viremia --> cross BBB and destroy motor neurons

13

what is post polio syndrome

inc weakness later in life

14

how are vaccine strains distinguished from wild poliovirus

strain specific polyclonal area (specialized labs only)

15

salk vs sabin vaccine

salk (IPV) = inactivated (by formalin); prevents reversion; protects against paralysis but NOT spread of wild virus

sabin (OPV) = live oral; protects againt paralysis AND spread of wild virus bit can be shed and revert and enter community

16

Which vaccine is used in US

Salk = IPV
global eradication program uses OPV

17

structure of polyoma virus

non-enveloped, icosahedral, dsDNA (circular genome)

18

where in the cell does the polyoma virus repliate

NUCLEUS

19

consequences of polyoma virus infection into permissive vs non-permissive cells

permissive = rep in nuc and lyse cell to release progeny

non-permissive = integrate into host genome and transform cell = tumor formation

20

genes responsible for transformation and immortilization of non-permissive cells

3 genes: small, middle, and large T antigens

immortalization = small and large T antigen
transformation = small and middle T antigen

21

what do the early genes of polyoma virus encode? late?

early = T antigens
late = structural protein

22

what are the 2 known human polyoma viruses

JC and BK

23

who gets infected with JC and BK virus? who gets cancer form them?

everyone gets infected but only AIDS and transplant pts get cancer

24

describe where the BK and JC viruses replicate in the body?

where they enter (GI or respiratory tract) --> viremia --> kidney, lung, brain

25

where do BK and JC virus have latent infection?

kindey
**in immunocomprosimed can lead to hemorrhagic cystitis

26

etiologic agent of PML

JC virus

27

What is PML

progressive demyelinating disease (lyses oligiodendrocytes) due to reactivation og JC virus

28

presentation of PML

over the course of a few weeks clumsiness, weakness, speech problems

29

diagnosis of PML made by

lesions in white matter on MRI
CSF or brain biopsy with PCR + for JC virus

30

prognosis of PML

transplant = 80% fatality in 6 mos
HIV/AIDS = 50% in 6 mos due to HAART therapy