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AU13 Biochemistry Final > Furci - Membrane Receptors and Endocytosis > Flashcards

Furci - Membrane Receptors and Endocytosis Flashcards

1
Q

Three cholesterol precursors

A

corticosteroids
androgens
estrogens

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2
Q

Steroid hormones immediately _____ out of _____ cells and into _______

A

diffuse
endocrine
bloodstream

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3
Q

Steroid hormones are _____ soluble (can cross the ______ _________)

A

lipid

cell membrane

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4
Q

Steroid hormones have __________ receptors located inside ____ cells

A

intracellular (cytoplasmic)

target

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5
Q

Steroid hormones are ______ ______ and have a ______ _____ than peptide hormones

A

slower acting

longer half-life

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6
Q

Polypeptide hormones do not immediately enter the _______; can be stored in _____ _____ ______

A

bloodstream

endocrine cell vesicles

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7
Q

Polypeptide hormones are _____ soluble

A

water

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8
Q

Polypeptide hormones do not readily pass through the ___ _______

A

cell membrane

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9
Q

Polypeptide hormones are termed the ______ ______; of which bind to ________ receptors (ligand)

A

first messengers

external

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10
Q

Polypeptide hormones’ _________ effects are mediated by “second messengers” (_______ reactions) - cAMP or Ca

A

intracellular

internal

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11
Q

This receptor has seven transmembrane-spanning α-helices (ligand binds to pocket)

A

G-protein coupled receptors

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12
Q

Calcium binds to _________ protein inducing a conformational change; two globular domains joined by a long α-helix

A

calmodulin

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13
Q

Phosphatidylinositol 4,5-bisphosphate (PIP2) is hydrolyzed by ________ to generate 2 second messengers; _________ and _________

A

PLC (phosophlipase C)
inositol trisphosphate (IP3)
diacylglycerol (DAG)

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14
Q

This second messenger derived from PIP2 is water soluble and mobilized calcium

A

inositol trisphosphate (IP3)

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15
Q

This second messenger derived from PIP2 is anchored in plasma membrane via ______ ______ ____ side chains and activates a key _____ _____ ___ family

A

diacylglycerol (DAG)
hydrophobic fatty acid
protein kinase C (PKC)

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16
Q

_______ ______ endocytosis is selective

A

receptor mediated

17
Q

Receptor mediated endocytosis involves the formation of _______ (containing _____) at the surface of membrane

A

vesicles

receptors

18
Q

_______ coated vesicles (form polyhedral lattice); it contains 3 ___ ____ and 3 ____ ____

A

clathrin

3 light chains and 3 heavy chains

AU13 Biochemistry Final (14 decks)

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