G- ESKAPE pathogens

Question 1

Diseases of actinobacter baumannii

Answer 1

Big in post-trauma infections, meningitis, bacteraemia, pneumonia

Question 2

diseases by pseudomonas aeruginosa

Answer 2

Big in colonizing aseptic medical devices, bacteraemia, pneumonia ~ major cause of pneumonia in individuals with cystic fibrosis

Question 3

physical attributes of acinetobacter baumannii

Answer 3

g-, strict aerobe! Commensal/environmental, motile (type IV pili),

Question 4

physical attributes of pseudomonas

Answer 4

g-, facultative anaerobe, environmental bacterium, motile (flagella and type IV pili)

Question 5

genome of acinetobacter

Answer 5

3.5 Mbp
60% accessory genome
Isolate specific genes ~ suggests hgt

Question 6

genome of pseudomonas

Answer 6

BIG
6.2 Mbp
10% core genome
Plasmids

Question 7

virulence factors acinetobacter

Answer 7

LPS, type IV secretion system, efflux pumps

Question 8

virulence factors of pseudomonas

Answer 8

Can grow in microaerophilic or anaerobic conditions
Anaerobic growth with nitrate or nitrite as a terminal electron acceptor

Growth in a diversity of environments
○ Able to grow on a range of different carbon and nitrogen sources
○ Able to grow in diesel and jet fuels causing microbial corrosion
Able to grow in cleaning agents and disinfectants

Question 9

resistance of Acinetobacter

Answer 9

Beta-lactams, aminoglycosides, quinolones using RND transporters

Question 10

Pseudomonas resistance

Answer 10

Carbapenems!!
Some are resistant to polymyxins, most other common antibiotics using RND transporters