Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Advanced Mol Cell > G-Protein Coupled Receptor > Flashcards

G-Protein Coupled Receptor Flashcards

1
Q

BASIC STRUCTURE OF GPCRs
How many TM helices make up the GPCR?
What pattern do the connecting loops take?

A

7 alpha helices
alternating intracellular and extracellular loops

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Where are the N and C-terminus located

A

N= extracellularly
C= Intracellularly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the main functions of the N and C-terminus

A

involved in ligand binding, receptor activation, and their interaction w/ downstream signalling molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Where is the G-protein binding site located

A

intracellularly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are G-proteins crucial for

A

mediators of signal transduction
causing signalling cascades

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what conformational change changes the a-subunit

A

GDP -> GTP
G-Protein activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what purpose does a dissociated G(alpha)- GTP have on proteins

A

regulation of downstream effectors and enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is G(alpha)i normal function

A

inhibits the activity of adenylyl cyclase
which converts ATP-> cAMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

when Gai is inactivated, what happens to the signalling pathway and the result of this

A

ATP will be converted into cAMP, with no end or stabilisation
this will lead to disease= whooping couch

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

physiological effects of inactivation of Gai

A

erosion of respiratory epithilium
large quantities of discharge, muscus containing fluid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what receptor activates Phopholipidase C(beta)

A

Gq(alpha)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what receptor activates Phopholipidase C(beta)

A

Gq(alpha)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

steps in the cAMP 2ndary messenger system

A
  1. ligand binding
  2. a-subunit binds to adenylate cyclase in membrane
  3. this activated enzyme catalyses formation of cAMP from ATP
  4. PKA phosphorylates protein (activates)
  5. initiates response in cell
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

In the Liver, when the Beta2 Adrenoceptor is activated what is the main goal of the receptor and signalling pathways

A

3 stages of alternating energy accumulation
GLYCOGENOLYSIS- breakdown of glycogen into glucose
GLUCONEOGENESIS- synthesis of glucose from non-carb sources (lactate etc)
LIPOLYSIS- breakdown of stored fats into fatty acids, used for energy production when in high demand

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Energy mobilisation in the liver due to the Beta2 Adrenoceptor

A

activation in the liver helps to mobilise energy reserves to meet the increased energy demands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

role of Glycogenolysis, vasodilation, enhanced muscle contraction, lipolysis and muscle glucose uptake in skeletal muscle when B2 Adrenoceptor is activated

A
  1. increase glucose stores in muscle
  2. increased blood flow to muscles= more oxygen and nutrients
  3. enhanced muscle contraction during physical activity
  4. production of fatty acids for energy production
  5. using glucose as an energy source
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

where can cGMP be found in the cell

A

receptor bound or ‘free’ in the cytoplasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what enzyme will remove the cAMP and cGMP molecules/ recycle

A

Phosphodiesterase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
  2. DAG, hydrophobic and will remain in the membrane
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

role of lipid kinases

A

phosphorylate groups of lipids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

activation of Phospholipase Cbeta to produce IP3- what will be released

A

Ca2+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Protein Kinase C (PKC) are activated by 2 molecules in 2 domains

A

DAG (in C1) and Ca2+ (in C2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

help to regulate over-stimulation of GPCRs (2 proteins/ mechanisms)

A

GRK- stops G-protein binding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

help to regulate over-stimulation of GPCRs (2 proteins/ mechanisms)

A

GRK- stops G-protein binding
Beta-arrestin= degrades/ recycle receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

help to regulate over-stimulation of GPCRs (2 proteins/ mechanisms)

A

GRK- stops G-protein binding
Beta-arrestin= degrades/ recycle receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

29
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

29
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
29
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

30
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

30
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

30
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

30
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

30
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

30
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

30
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
30
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

31
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

31
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

31
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

31
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
31
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

31
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

31
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

31
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

32
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

32
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

32
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

32
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

32
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

32
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

32
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

32
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
33
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

33
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
33
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

33
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

33
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

33
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

33
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

34
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

35
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

35
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

35
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

35
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
35
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

35
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

35
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

36
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

37
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

37
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

37
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
37
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

37
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

37
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

38
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

38
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

39
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

39
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
39
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

39
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

39
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

40
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

40
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

40
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

41
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

41
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

41
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

42
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

42
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

42
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

42
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
42
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

43
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

43
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

43
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

43
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

43
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

43
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

43
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
43
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

44
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

44
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

44
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
44
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

44
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

44
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

44
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

44
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

45
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

45
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

45
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
45
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

45
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

45
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

45
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

46
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

47
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

47
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

47
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

47
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

47
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

47
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

47
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
47
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

48
Q

whooping cough- what g-protein is affected and the result to that protein

A

It is an inactivated Inhibitory G-Protein

48
Q

Uveal melanoma- and mutations of the Gq a-subunit
what is the result of this mutation?

A

blocking of GTP hydrolysis

48
Q

what receptor activates adenylyl cyclase

A

Gi(alpha)

48
Q

phospholipase Cbeta is an example of what?

A

Hydrophobic lipid in the membrane

48
Q

maintenance of Ca2+ levels is driven by what factor/ pump

A

ATP-driven Ca2+ pumps

48
Q

Lipases will target membrane lipids in order to generate 2 kinds of 2nd messengers, name the main 2

A
  1. IP3- water soluble, diffuse through the cytoplasm
49
Q

what does the G(beta-gamma) complex do after dissociation, in terms of proteins and signalling

A

ACTIVATE or INHIBIT various signalling pathways, enzymes

49
Q

5 processes regulated by Ca2+ signalling

A

synaptic transmission
hormone secretion and synthesis
fertilisation
Muscle contraction
Cytokinesis

Advanced Mol Cell (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions