membran econtract sites Flashcards
1
Q
what are membrane contact sites
A
specialised regions where membranes of 2 organelles come in close proximity w/o fusing
2
Q
Reasons for MCS
A
exchange of lipids and ions
protein exchange
3
Q
role of tethering proteins in MCS
A
bring the 2 membranes together/ close
adhered to both membranes
anchor and bridge the gap between
4
Q
example of tethering protein
A
VAP (VAMP associated Protein)
5
Q
present proteins for MCS, role in exchange
A
Lipid transfer Proteins- CERT- facilitate specific lipid trafficking
Calcium channels- IP3R, VGCC voltage gated calcium channels
Signalling proteins- Kinases and phosphates
6
Q
A
