G-protein–linked 2nd messengers

Question 1

a1

Answer 1

Sympathetic

q

INC vascular smooth muscle contraction
INC pupillary dilator muscle
contraction (mydriasis)
INC intestinal and bladder sphincter muscle
contraction

Question 2

a2

Answer 2

Sympathetic

i

INC platelet aggregation
DEC sympathetic (adrenergic) outflow
DEC insulin release
DEC lipolysis
DEC aqueous humor production

Question 3

b1

Answer 3

Sympathetic

s

INC heart rate
INC contractility
INC renin release
INC lipolysis

Question 4

b2

Answer 4

Sympathetic

s

Vasodilation
bronchodilation
ciliary muscle relaxation
INC lipolysis
INC insulin release
INC aqueous humor production
DEC uterine tone (tocolysis)

Question 5

b3

Answer 5

Sympathetic

s

INC lipolysis
INC thermogenesis in skeletal muscle

Question 6

M1

Answer 6

Parasympathetic

q

• CNS
• enteric nervous system

Question 7

M2

Answer 7

Parasympathetic

i

DEC heart rate and contractility of atria

Question 8

M3

Answer 8

Parasympathetic

q

INC exocrine gland secretions (eg, lacrimal, sweat, salivary, gastric acid)
INC gut peristalsis
INC bladder contraction
INC pupillary sphincter muscle contraction (miosis)
bronchoconstriction
ciliary muscle contraction
(accommodation)

Question 9

D1

Answer 9

Dopamine

s

Relaxes renal vascular smooth muscle

Question 10

D2

Answer 10

Dopamine

i

Modulates transmitter release, especially in brain

Question 11

H1

Answer 11

Histamine

q

INC nasal and bronchial mucus production
INC vascular permeability
contraction of bronchioles
pruritus
pain

Question 12

H2

Answer 12

Histamine

s

INC gastric acid secretion

Question 13

V1

Answer 13

Vasopressin

q

INC vascular smooth muscle contraction

Question 14

V2

Answer 14

Vasopressin

s

INC H2O permeability and reabsorption in collecting tubules of kidney

(V2 is found in the 2 kidneys)