gall bladder Flashcards
(29 cards)
hepatic arch zone 1
portal aea; 1st to suffer toxins or viral hepatitis
hep zone 2
in between
hep zone 3
CV area–1st to suffer ischemia, etoh hep
space of disse
perisinusoidal space between fenestrated endo & cords
basal surface of hepatocytes comms w/ sinusoid via space of disse
gap jx sep but allow passage of ions and water
hepatocyte secretion into bile canniculus is an
active process (bile salt pump)— needs microvllli and cytoskeleton
cholangiocytes add
H20 ad HCO3-
what concentrates hepatic bile
na pumps
3 components of gallstone formation
increase cholesterol
decease bile acids
decrease phospholipids
2 fux of bile
fat digestion and absorption
elimination of waste: cholesterol
where are bile acids reabsorbed
terminal ileum
gilbert syndrome
problems w/ uptake–>increase unconj
crigler-najjar
problem w/ conj–>incr conj
dubin johnson/rotor
probs w/ excretion–inc conj
pregnancy can cause
benign intrahepatic ostruction secondary to increased estrogen
what do cholseterol stonse look like
yellowish and radiolucent
pigment stones are
radiopaque
the smaller the stone
more likely it is to cause problems
labs in cholecystitis
increase billi, AST, ALT, WBC w/ left shift
Rokitasky-Aschoff sinus
entrapped crypts form pseudodiverticula or pockets in GB wall
porcelian gallbladder
extensive calcifications–variant of chronic chole
increase risk of gb carcinoma
strawberry gallbladder
choleseral esters accum in lamina propia–>speckled yellow surface
foamy lipid laden mos
labs in choledocholithiasis
increase billi, ALP, AST, ALT
risk factors of gb carcinoma
galllstonse, chronic ccitis, chronic infx, primary sclerosing cholangitis
klatskin’s tumor
cholangicarcinoma
malig of bile ducts
