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Flashcards in tumor of small & lg bowel Deck (22)
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0
Q

Peutz-Jegher Syndrome

A

AD disesase resulting in multiple benign hamartomas (mature but abnormally arranged in tissue) in entire GI tract (esp small intestine) + buccal melanin pihmentation abnormalities

polyps benign but >50% change of developing CRC

1
Q

FAP

A

AD mutation of APC or AR of MUTYH (DNA repair)

2
Q

HNPCC

A

NO POLYPS
but AD mutation of mismatch repair genes
most common inherited

3
Q

known carcinogens

A

fecal bile acids
heterocyclic amines-mutagenic degradation products
fecapentenes-glycerol ethers produced by anaerobic breakdown of fatty acids
3- ketosteroids- oxidation products of cholesterol- carcinogenic in-vitro

4
Q

potential protective measures

A

NSAIDs–>COX2 inhibs
Ca nd vitD–>bind fatty acid and bile acids
folic acid def–>dna hypermethy

5
Q

Turcot syndrome

A

APC mutations and CNS

6
Q

Gardner syndrome

A

APC mutations- ossesous and soft tissue, retinal depigmentation

7
Q

juvenile polyposis

A

involves LP

hamartamous encosilating dilated cystic glands in children <5

8
Q

extra intenstinal FAP

A

duodenal and desmoid tumors Mc of death

9
Q

Lynch 1

A

HNPCC CRC only

10
Q

Lynch II

A

HNPCC CRC + other malig esp endometrial cnacer

11
Q

polyps of HNPCC tend to be

A

large w. villous or dysplastic component
flat/serrated adenomas
mostly in prox colon
aggressive in nature

12
Q

amsterdam criteria for HNPCC

A

3-2-1 rule
3 relatives with HNPC associated cancer
> 2 successive generations
>1 relative diagnosed before 50

13
Q

other ways to dx HNPCC

A

microsatellite instability

IHC for MMR genes

14
Q

neoplastic

A

adenoma

15
Q

nonneoplastic

A

hyperplastic
hamartomous
inflam pseudopolyps

16
Q

risk of malignancy

A

size >2cm
VA>TVA>TA
high grade dysplasia
multiplicity

17
Q

invasive adenocarcinoma of distal colon

A

napkin ring lesions
annular, circumferential, ulcerated mass
obstruction common

18
Q

right sided (prox colon) exophytic mass

A

polypoid, exophytic mass
may still be deeply infiltrating
obstruction uncommon
occult bleeding or melena

19
Q

carcinoid tumors of SH

A

secrete bioactive amines–>5HT

if goes through liver–>metabolized–>5HIAA in urine

20
Q

adenosarcoma of SB is mostly

A

duodenum and prox jejunum

21
Q

gist

A

gastrointestinal stronal tumor

mesenchymal tumor resembling modified smooth mucle and neural tissue
CD115 positive (ckit tyrosine kinase)