Gallium

Question 1

how is gallium-67 citrate made

Answer 1

cyclotron produced by bombarding Zn 68 with protons

Question 2

4 energies of Ga-67

Answer 2

93 keV, 184 keV, 296 keV, 394 keV

Question 3

how does GA-67 act in body

Answer 3

acts like iron and binds to variety of plasma proteins (transferrin receptors would bind to Ga-67)

Question 4

clinical indications

Answer 4

1- tumor localilization- lymphoma
2- inflammatory processes- sarcoidosis
3- infection- osteomyelitis
4- FUO

Question 5

pt prep

Answer 5

none

Question 6

Ga is insoluble so we have to add what

Answer 6

insoluble ion so add citrate (-3 ion) into resulting complex to become neutral solution for injection

Question 7

dose

Answer 7

10 mCi

Question 8

collimator

Answer 8

medium

Question 9

imaging times for inflammation or infection

Answer 9

delay-48-72 hr

Question 10

imaging times for tumor

Answer 10

delays on day 3 and 5

Question 11

imaging times for Bone/Ga

Answer 11

delays 48-72 hrs
earlier delays when looking at spine

Question 12

biodistribution

Answer 12

bone, bone marrow, live, genitourinary, GI tract, salivary glands and lacrimal glands
spine images either pos or neg

Question 13

persistent renal activity may indicate

Answer 13

iron overload, lymphoma, chemo drugs, hepatic failure, vasculitis

Question 14

diffused colon activity

Answer 14

inflammatory conditions, ulcerative colitis, psuedomembrane colitis

Question 15

decr liver uptake

Answer 15

severe liver disease, iron overload, recent chemo