Gastric Cancer Flashcards Preview

Year 5 Cancer > Gastric Cancer > Flashcards

Flashcards in Gastric Cancer Deck (16)
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1
Q

def

A

stomach cancer is a tumour in any part of the stomach

2
Q

what are the most common gastric cancers

A

adenocarcinomas

3
Q

what are less common gastric cancers

A

lymphoma

leiomyosarcoma

4
Q

epi

A

men>women

more common in east asia (china, japan)

5
Q

aetiology

A

consumption of smoked and salted foods

lack of refrigeraion

6
Q

what infection is associated with gastric cancer

A

h pylori

7
Q

how does h pylori increase risk of gastric cancer

A

increases mutations in p53

8
Q

what tumour suppressor gene is associated with gastric cancer

A

mutated p53 (loss of tumour suppressor function)

9
Q

what proto-oncogenes are associated with gastric cnacer

A

ras

c-myc

10
Q

what are risk factors for gastric cancer

A

STOMACH

Smoking, Smoked foods, Syndromes (Lynch syndrome)
Talcum powder
Obesity
Menetriers DIsease
Anaemia (pernicious), Alcohol
Chronic ulcer or gastritis
H. pylori or High salt diet
11
Q

features of gastric cancer

A

LIONS

Lump (epigastric)
Insidious onset symptoms (epigastric pain and weight loss)
Obstructive features
New onset dyspepsia
Silent presentation (lymph nodes such as virchows node, sister mary josephs nodule, irish node)

patients are commonly elderly and male with a smoking background and FHx of GC

12
Q

what is virchows node

A

left supraclavicular node

13
Q

what is sister mary josephs nodule

A

periumbilical nodule

14
Q

what is irish node

A

left axillary node

15
Q

what is the first line investigation for GC

A

upper GI endoscopy with biopsy

-ulcer or mass

16
Q

what is menetriers disease

A

pre-malignant disease of stomach

massive gastric folds with excessive mucous production and reduced acid production