Y5 - Ovarian tumour (benign and malignant) Flashcards Preview

Year 5 Cancer > Y5 - Ovarian tumour (benign and malignant) > Flashcards

Flashcards in Y5 - Ovarian tumour (benign and malignant) Deck (34):
1

what provides a definitive diagnosis of ovarian cancer

surgery

2

def of an epithelial ovarian cancer

a malignant transformation of the ovarian capsule epithelium

3

what are different sub-types of ovarian cancer

epithelial, germ cell, and sex-cord tumours

4

aetiology

genetic causes implicated
-BRCA1/2
-HNPCC mutations

5

where do ovarian cancers often originate

the fallopian tubes at the distal fimbral portion

6

does epithelial ovarian cancer invade organ space

normally no, usually attaches to the surface of organs

7

epi

most lethal gynaecological cancer
elderly

8

is ovarian cancer more common in white women or black women

white women

9

RFs

increasing age
FHx of ovarian/breast cancer
never used OCP

10

what does OCP protect against

ovarian cancer

11

signs and symptoms

RFs
pelvic mass
-adnexal mass
GI symptoms > 3 months
-bloading
-nausea
-dyspepsia
-urinary incontinence

12

features of BRCA1 mutation

found on chr 17q
autosomal dominant

13

what is the increased risk of ovarian cancer with a BRCA1 mutation

35% increased lifetime risk

14

features of BRCA2 mutation

found on chr 13q

15

what is the increased risk of ovarian cancer with a BRCA2 mutation

30%

16

first line investigation

pelvic ultrasound
-solid mass
-high blood flow (doppler)

17

what cancer antigen marker is raised in ovarian cancer

CA 125

18

what is the definitive test for ovarian cancer

surgery and histopathology

19

why do patients commonly present at late stages of ovarian cancer

due to vague and non-specific symptoms

20

what are the four stages of ovarian cancer

Stage 1 - confined to ovaries
Stage 2 - involves pelvic extension or primary peritoneal cancer
Stage 3 - spread to the peritoneum outside the pelvis or metastasis to retroperitoneal lymph ndoes
stage 4 - distant metastasis

21

what are the cornerstones of ovarian cancer treatment

surgery and chemotherapy

22

what is standard therapy for ovarian cancer

maximal surgical debulking and chemotherapy

23

management for stage I ovarian cancer

surgery

24

management for stages II-IV ovarian cancer with optimal debulking

IV and intraperitoneal chemotherapy with paclitaxel and cisplatin

25

management for stages II-IV ovarian cancer with sub-optimal debulking

IV chemotherapy with carboplatin and paclitaxel OR docetaxel

26

management for platinum sensitive recurrent disease

carboplatin and paclitacel or doxorubicin liposomal

27

management for platinum resistant recurrent disease

doxorubicin liposomal

28

prevention for ovarian cancer

OCP

29

complications

intraperitoneal therapy failure
plantar-palmar erythrodysaesthesia
alopecia

30

what causes plantar-palmar erythrodysaesthesia

doxorubicin liposomal

31

what is plantar-palmar erythrodysaesthesia

paraesthesia with painful redness of palms and soles

32

prognosis

majority of patients have remission after first line therapy

33

what is the most important prognostic factor for relapse

treatment-free interval or time from completion of first line therapy to reoccurrance

34

what has worse prognosis, platinum sensitive or platinum resistant ovarian cancer

platinum resistant