Gastric Disease Flashcards
Gives causes of acute gastritis
Chemical irritation/burns
Trauma
What are the 3 main causes of chronic gastritis?
Chemical insult
Bacterial (H. pylori)
Autoimmune disease
What happens in autoimmune gastritis?
Antibodies destroy parietal cells + intrinsic factor
Can lead to pernicious anaemia
What is the most common bacteria that causes bacterial gastritis?
H. pylori
How does chemical insult affect the stomach?
Dissolves + destroys lipid bilayer, causing inflammation, hyperplasia and ulcers
Define “peptic ulceration”
Breach of the GI mucosa by acid/pepsin attack
Where are common sites for peptic ulcers?
Duodenum (1st part)
Stomach
Gastro-oesophageal junction
Name some benign gastric tumours
Mainly polyps - hyperplastic polyps or fundic gland polyps
Name some malignant gastric tumours
Adenocarcinoma
Lymphomas
Gastrointestinal stromal tumours (GISTs)
Where do adenocarcinomas of the stomach tend to develop?
Proximally (GO junction, cardia)
Pernicious anaemia is a premalignant condition. True/False?
True
Intestinal type gastric adenocarcinoma has better prognosis than diffuse type. True/False?
True
From which tissue is gastric lymphoma derived?
MALT (mucosal-associated lymphoid tissue)
What is gastroparesis?
Delayed gastric emptying that is NOT due to obstruction
Give examples of symptoms of gastroparesis
Feeling of fullness, bloating
Nausea, vomiting
Weight loss
Abdominal pain
