Gastro

Question 1

Anti-emetic for motion sickness

Answer 1

Hyoscine

Anticholinergic

Question 2

Anti-emetic of the histamine class

Answer 2

Cyclizine

Question 3

Anti-emetic acting on 5HT3-R

Answer 3

Antagonists of 5HT3

Ondansetron

Question 4

Anti-emetic acting on Dopamine

Answer 4

Dopamine Antagonists

Metoclopramide, Domperidone, Prochlorperazine

Question 5

Anti-emetic to be avoided in PD and in young women

Answer 5

Metoclopramide- crosses BBB
PD: worsens Parkinsonian Sx
young F: occulogyric crises and

Question 6

effect of aspirin on the stomach

Answer 6

• direct irritant of the gastric mucosa
• reduction in PGE2 (usually increases mucus and HCO3 secretion)
• reduction in PGI2 (usually increases gastric blood flow to eliminate acid that had diffused into submucosa)
• antiplatelet effect: propogation of any gastric bleeding.