Gastrointestinal Flashcards

(50 cards)

1
Q

What questions should be asked regarding passage of stool in GI conditions?

A
  • How often
  • How hard
  • Is it painful
  • Has there been a change?
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2
Q

What is normal stool frequency?

A

Very variable - from 4 per day to 1 a week

Depending on age + diet

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3
Q

What are the advantages of stool softening medication in constipation?

A
  • Non invasive

- Can be given by parents

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4
Q

What are the disadvantages of stool softening medication in constipation?

A
  • Non compliance

- Side effects

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5
Q

What treatment is used for impaction?

A
  • Empty impacted rectum
  • Empty colon
  • Maintain regular stool passage
  • Slow weaning off treatment
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6
Q

What may be investigated in history and examination in suspected IBD?

A
  • Intestinal symptoms
  • Extra-intestinal manifestations
  • Exclude infection
  • Family History
  • Growth and sexual development
  • Nutritional status
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7
Q

List types of vomiting in children

A
  • Vomiting with retching
  • Projectile vomiting
  • Bilious vomiting
  • Effortless vomiting
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8
Q

How may a child present in pre-ejection phase of vomiting with retching?

A
  • Pallor
  • Nausea
  • Tachycardia
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9
Q

List some stimulants of the vomiting centre in children

A
  • Enteric pathogens
  • Intestinal inflammation
  • Metabolic derangement
  • Infection
  • Head injury/tumour
  • Visual stimuli
  • Middle ear stimuli
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10
Q

What are the causes of bilious vomiting?

A
Intestinal atresia (in newborns)
Malrotation +/- volvulus
Intussuception
Ileus 
Crohn's disease w strictures
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11
Q

What investigations may be done for bilious vomiting?

A
  • Abdominal xray
  • Contrast meal
  • Surgical opinion re exploratory laparotomy
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12
Q

What are the causes of effortless vomiting?

A

Almost always - GORD

Cerebral palsy, Progressive neuro problems, Oesophageal atresia +/- TOF operated, Generalised GI motility problem

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13
Q

What can barium swallow be useful in the diagnosis of?

A
  • Dysmotility
  • Hiatus hernia
  • Reflux
  • Gastric emptying
  • Strictures
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14
Q

What feeding advice may be given in reflux?

A
  • Fluid thickeners
  • Appropriateness of foods
  • Behavioural programme (Oral stimulation/Remove adverse stimuli)
  • Feeding position
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15
Q

What nutritional advice may be given in reflux?

A
  • Calorie supplements
  • Exclusion diet (milk free)
  • Nasogastric tube
  • Gastrostomy
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16
Q

What medical treatment may be given in reflux?

A
-Feed thickener
  Gaviscon  
  Thick & Easy
-Prokinetic drugs 
-Acid suppressing drugs
        H2 receptor blockers
         Proton pump inhibitors
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17
Q

What are some indications for surgery in reflux?

A

-Failure of medical treatment

Persistent - Failure to thrive/Aspiration/Oesophagitis

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18
Q

What are the functions of the small intestine?

A

Enormous surface area of small intestine
-For absorption - Folds, Villi

Essential secretory component

  • Water for fluidity/enzyme transport/absorption
  • Ions e.g. duodenal HCO3-
  • ? Defence mechanism against pathogens/harmful substances/antigens
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19
Q

What usually causes osmotic diarrhoea?

A

Malabsorption

Allergy, Coeliac, CF

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20
Q

What usually causes secretory diarrhoea?

A

Toxin production eg from Cholera and enterotoxigenic E. coli

Can be inflammatory - IBD

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21
Q

What are causes of motility diarrhoea?

A
  • Toddler’s diarrhoea

- IBD, Congenital hyperthyroidism, Chronic intestinal pseudo-obstruction

22
Q

How can you tell the difference between osmotic and secretory diarrhoea?

A

If you make the patient NBM -

Osmotic diarrhoea will stop. If it doesn’t - most likely secretory.

23
Q

What types of condition can cause fat malabsorption?

A

-Pancreatic Disease
(Diarrhoea due to lack of lipase. Ie CF)

-Hepatobiliary Disease
(Chronic liver disease, cholestasis)

24
Q

List some liver function tests (LFTs)

A
  • Bilirubin (Total/Split - conjugated/unconjugated)
  • ALT/AST (alanine aminotransferase/aspertate aminotransferase)
  • Alkaline phosphatase
  • Gamma glutamyl transferase (GGT)
25
Which LFTs would be elevated in hepatocellular damage?
ALT - Alanine aminotransferase AST - Aspartate Aminotransferase
26
Which LFTs would be elevated in biliary disease?
Alkaline phosphatase Gamma glutamyl transferase (GGT)
27
List some tests to use to assess liver function?
``` -Coagulation (PT/INR) APTT -Albumin -Bilirubin -(Blood glucose) -(Ammonia) ```
28
List signs of chronic liver disease in children
``` Jaundice Encephalopathy Epistaxis Varices with portal hypertension Spider naevi Muscle wasting Bruising and petechiae Splenomegaly Clubbing Ascites Peripheral neuropathy Rickets ```
29
What is haem broken down into?
Biliverdin -> Unconjugated bilrubin
30
What is used to conjugate bilirubin?
UDP glucuranyl transferse
31
What is conjugated bilirubin converted into?
Bile
32
Which form of bilirubin is water soluble?
Conjugated bilirubin
33
What type of bilirubin is mostly involve in pre-hepatic jaundice?
Unconjugated
34
What type of bilirubin is mostly involve in post-hepatic jaundice?
Conjugated
35
What are the causes of early jaundice (<24hrs)?
Haemolysis, Sepsis | Always pathological cause!
36
What are the causes of intermediate jaundice (24hrs-2wks)?
- Physiological, - Breast milk, - Sepsis, - Haemolysis
37
What are the causes of prolonged jaundice (>2wks)?
- Extrahepatic obstruction, - Neonatal hepatitis, - Hypothyroidism, - Breast milk
38
What are the reasons for physiological jaundice?
- Shorter RBC life span - Relative polycythaemia - Relative immaturity of liver function
39
What are some causes of haemolysis leading to early/intermediate unconjugated jaundice?
- ABO incompatibility - Rhesus disease - Bruising/cephalhaematoma - Red cell membrane defects (Spherocytosis) - Red cell enzyme defects (G6PD)
40
What are some causes of abnormal conjugation leading to early/intermediate unconjugated jaundice?
- Gilbert's Disease | - Crigler-Naijar syndrome
41
What are some causes of conjugated prolonged infant jaundice?
Biliary construction | Neonatal hepatitis
42
Does conjugated jaundice always require further investigation?
Yes
43
What are some causes of biliary obstruction?
- Biliary atresia - Choledochal cyst - Alagille syndrome (Intrahepatic cholestasis, dysmorphism, congenital cardiac disease)
44
What are some causes of neonatal hepatitis?
- Alpha-1-antitrypsin deficiency - Galactosaemia - Tyrosinaemia - Urea cycle defects - Haemochromatosis - Glycogen storage disorders - Hypothyroidism - Viral hepatitis - Parenteral nutrition
45
What test is used to differentiate unconjugated jaundice from conjugated jaundice?
Split bilirubin
46
What in energy needed for in children?
Physical activity Thermogenesis Tissue maintenance Growth
47
What risks surround infant nutrition?
- Infants can rapidly become malnourished. - Dependent on carer - High demands for growth and maintenance - Low stores (Fat and protein) - Frequent illness
48
What are the benefits of breast milk?
- Nutritionally best for full term babies - Improves cognitive development - Reduces infection
49
Roughly how long is milk the exclusive feed in infants?
4-6 months
50
What is the first line feed choice in cows milk protein allergy?
-Extensively hydrolysed protein feeds | Second line - amino acid based feeds