Gastrointestinal Motility (Laxatives/Antidiarrheals) Flashcards Preview

Pharmacology II > Gastrointestinal Motility (Laxatives/Antidiarrheals) > Flashcards

Flashcards in Gastrointestinal Motility (Laxatives/Antidiarrheals) Deck (12):
1

Cholinomimetic Agents

-stimulate GI motility

Ex. Bethanechol
Use: post-op urinary retention

2. Neostigmine

2

Metoclopramide

-dopamine receptor antagonist
-Effect on the esophagus and stomach

3

Erythromycin

Uses: acute upper gastrointestinal hemorrhage to promote gastric emptying of blood before endoscopy

4

Constipation treatment algorithm

-diet modification, add fiber
-Add osmotic laxative (ex. PEG) for 2-4 weeks
-Add stimulant laxative
-Lubriprostone or linaclotide

5

Milk of magnesia

-Non absorbable salt
-osmotic laxative
-risk of hypermagnesemia in renal insufficiency

6

Purgatives

-harsh, meant to force a bowel movement in 1-3 hours
-Ex. magnesium citrate, sodium phosphate

sodium phosphate ADE: hyperphosphatemia, hypocalcemia, hypernatremia, hypokalemia

7

Polyethylene glycol (PEG)

Ex. Miralax

-great because it doesn't cause cramps or flatus
-No significant electrolyte shifts since this is a balanced preparation

8

Anthraquinone Derivatives

Ex. Aloe, senna, cascara

Chronic use: brown pigmentation of the colon "melanosis coli"**

9

Acute versus Chronic diarrhea

Acute: <3 days
Chronic: >14 days

10

Contraindications for antidiarrhea agents

-bloody diarrhea
-high fever
-systemic toxicity

11

Bile Salt-Binding resins

Ex. chollestyramine, colestipol, or colesevelam

-can bind other drugs and reduce absorption

12

Antisecretory: Ex. Octreotide

Ex. Somatostatin

-inhibits secretion of numerous hormones and transmitters

ADE: steatorrhea, fat-soluble vitamin deficiency