Gen Derm

Question 1

What two types of amyloidosis are AL (light chain typically gamma) derived?

Answer 1

Nodular amyloidosis

Primary systemic amyloidosis

Question 2

What protein derivation is secondary systemic amyloidosis?

Answer 2

AA (non-immunoglobulin protein; amyloid associated)

Question 3

What protein is hemodialysis associated amyloidosis derived?

Answer 3

Beta 2 micro globulin

Question 4

What two types of systemic amyloidosis are derived from protein TTR (transthyretin)?

Answer 4

Senile systemic amyloidosis

Familial amyloidosis

Question 5

What 3 periodic fever syndromes contribute or can cause secondary systemic amyloidosis?

Answer 5

Muckle wells
Familial Mediterranean fever
TRAPS (TNF receptor associated periodic syndrome)

Question 6

What 3 cutaneous amyloidosis are keratinocyte derived?

Answer 6

Macular amyloidosis
Lichen amyloidosis
Secondary cutaneous amyloidosis

Question 7

Porphyrins light at what wavelength?

Answer 7

400-410nm

Question 8

Enzyme deficiency in congenital erythropoietic porphyria

Answer 8

UPS : uroporphyrinogen III co synthase

Question 9

Erythropoietic proto porphyria (EPP) enzyme deficiency?

Answer 9

Ferrochelatase

Question 10

Porphyria cutanea tarda (PCT) deficiency enzyme?

Answer 10

Uroporphyrinogen decarboxylase (UD)

Question 11

Enzyme deficiency Acute intermittent porphyria?

Answer 11

Porphobilinogen deaminase

Question 12

Enzyme deficiency Variegate porphyria?

Answer 12

Protoporphyrinogen oxidase (PPO)

Question 13

Enzyme deficiency of hereditary coproporphyria?

Answer 13

Coproporphyrinogen oxidase (CPO)

Question 14

Enzyme deficiency in Hepatoerythropoietic porphyria?

Answer 14

Uroporphyrinogen decarboxylase (UD)

Question 15

Two names for Type 1 familial hyperlipidemia

Answer 15

Familial LPL deficiency

Familial hyperchylimicronemia

Question 16

Defect in type 1 hyperlipidemia

Answer 16

Decrease lipoprotein lipase or apoprotein CII defect

Question 17

What labs are increased in type 1 hyperlipidemia

Answer 17

Increase TG (chylomicrons)

Question 18

What clinical findings in type 1 hyperlipidemia?

Answer 18

Eruptive xanthomas
Acute pancreatitis
Abd pain
Lipemia retinalis

Question 19

What crystals are seen in gout?

Answer 19

Needle like crystals of mono sodium urate

Question 20

What happens to gout crystals under polarized light?

Answer 20

Negative birefringence

Yellow parallel to red filter

Question 21

What crystals are seen in pseudogout?

Answer 21

Calcium pyrophosphate dihydrate (CPPD) crystals within joints
Rhomboid shape

Question 22

What happens to pseudogout crystals under polarized light?

Answer 22

Weakly positive birefringence

Blue when parallel to red filter

Question 23

Most common cosmetic preservative to cause ACD.

Answer 23

Quarternium-15

Question 24

What rubber accelerator is found in rubber shoes, gloves, elastic, fungicides

Answer 24

Thiuram

Question 25

Thiuram reacts with what?

Answer 25

Disulfram

Question 26

Most common allergic shoe dermatitis

Answer 26

Mercaptobenzothiazole (MBT)

Question 27

What is the rubber component in elastic undergarments that when washed with hypochlorite causes more allergenic and results in elastic dermatitis or "bleached rubber syndrome"

Answer 27

Carba mix or carbamates

Question 28

What textile mix causes purpuric contact dermatitis when clothes fits tightly

Answer 28

Ethylene urea melamine formaldehyde mix

Question 29

Fast acting adhesive found in super or Krazy glue, liquid bandages, and dermabond

Answer 29

Cyanoacrylate

Question 30

Artificial nails (adhesive)

Answer 30

Ethyl acrylate

Question 31

Artificial nails, dental fillings/sealants, glue or bone cement for artificial joints

Answer 31

Methacrylate

Question 32

What adhesive commonly seen in dentist orthopedic surgeon may diffuse through intact surgical glove and cause paresthesias

Answer 32

Methacrylate

Question 33

Contact allergen in sunscreen blocking UVB

Answer 33

PABA (padimate O)

Question 34

Contact allergen in sunscreen blocking UVA

Answer 34

Oxybenzone

Question 35

PABA cross reacts with what 4 substances or meds

Answer 35

Sulfonamides Azo dyes Benzocaine PPD

Question 36

What is the most common sunscreen agent to cause photo allergic contact dermatitis

Answer 36

Oxybenzone

Question 37

What 3 steroids are in group A?

Answer 37

Hydrocortisone acetate Prednisone Methylprednisolone

Question 38

What 5 corticosteroids are found in group B?

Answer 38

``` Triamcinolone acetonide Desonide Fluocinolone acetonide Fluocinonide Halcinonide ```

Question 39

What 3 steroids are in group D?

Answer 39

Hydrocortisone-17-vale rate/butyrate Clobetasol-17-butyrate Clobetasol propionate Betamethasone valerate/diproprionate

Question 40

What contact allergen is in group A steroids?

Answer 40

Tixocortol-21-pivalate

Question 41

What contact allergen is used in group B steroids?

Answer 41

Budesonide (also used in some group D steroids)

Question 42

What contact allergen for group D steroids?

Answer 42

Hydrocortisone-17-butyrate

Question 43

What allergen is found in permanent hair dye, black henna, temporary tattoos, photographic developer

Answer 43

PPD (paraphenylenediamine) | "Permanent pilar dye"

Question 44

Schnitzler's syndrome

Answer 44

Urticarial vasculitis & monoclonal IgM gammopathy & at least 2 of following: fever, arthralgias, ESR, WBC, bone abnormality, bone pain