Gene Mapping Flashcards

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1
Q

Through what process do children inherit a ‘patchwork’ of parental chromosomes (never exact copies)?

A

Genetic recombination

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2
Q

What is independent assortment?

A

Independent assortment is a genetic term that refers to the variation of chromosomes, or genetic information, during sex cell division. This variation allows for genetic differentiation in offspring.

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3
Q

What happens if alleles are close together on homologous chromosomes?

A

There is little chance of recombination

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4
Q

What does recombination frequency range from?

A

zero to 0.5

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5
Q

What Greek letter signals the recombination frequency?

A

Theta

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6
Q

What happens if alleles are far apart on homologous chromosomes?

A

There is a high chance of recombination (can be as high as 50%)

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7
Q

What does the term ‘linkage’ refer to?

A

Tendency of alleles to transmit together
- More linkage = less independent assortment
- Larger recombination frequency (theta) will suggest the alleles are unlinked

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8
Q

How can linkage equilibrium be studied?

A

By studying the levels of different alleles in entire populations
- The levels of different genes found together in different people
- Can then see what genes travel together

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9
Q

What is the expected frequency of 2 genes found together?

A

0.45

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10
Q

If the frequency of 2 genes is found to be higher than 0.45 what is to be said about the haplotype?

A

The haplotype is in linkage disequilibrium
- If <0.45 the haplotype is in linkage equilibrium

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11
Q

If genes are closer together will genes display linkage equilibrium or disequilibrium?

A

Linkage disequilibrium

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12
Q

What does the likelihood of genes seperating (recombining) depend on?

A

Distance apart and size of population

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13
Q

What 2 factors affect linkage disequilibrium?

A
  • Genetic disequilibrium
  • Time alleles have been present in population
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