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Flashcards in General Deck (8)
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1
Q

What is co-dominance?

A

A pair of alleles in a heterozygote are equally dominant and result in a mixed phenotype

2
Q

What is NADPH required for?

A
  • reducing power for biosynthesis
  • maintenance of GSH levels
  • detoxification reactions
3
Q

What does the pentose phosphate pathway produce?

A
  • NADPH
  • C5-sugar ribose
  • CO2
4
Q

What rate-limiting enzyme is used in the pentose phosphate pathway?

A

Glucose-6-phosphate dehydrogenase

5
Q

What is the pattern of inheritance in glucose-6-phosphate dehydrogenase deficiency?

A

X-linked recessive

6
Q

Which cell gets it’s only NADPH source from the pentose phosphate pathway?

A

RBCs

7
Q

What abnormality if found in a blood sample of a patient with glucose-6-phosphate dehydrogenase deficiency? Why do they form?

A

Heinz bodies

Hb becomes cross-linked due to inappropriate disulphide bond formation - forms an insoluble aggregate called Heinz bodies

8
Q

What are the differences between fibrous and globular proteins?

A

Fibrous - support, shape and protect. Long strands/sheets. Have a single type of repeating secondary structure.

Globular - involved in catalysis and regulation. Compact shape. Have several types of secondary structures