What is co-dominance?
A pair of alleles in a heterozygote are equally dominant and result in a mixed phenotype
What is NADPH required for?
- reducing power for biosynthesis
- maintenance of GSH levels
- detoxification reactions
What does the pentose phosphate pathway produce?
- C5-sugar ribose
What rate-limiting enzyme is used in the pentose phosphate pathway?
What is the pattern of inheritance in glucose-6-phosphate dehydrogenase deficiency?
Which cell gets it’s only NADPH source from the pentose phosphate pathway?
What abnormality if found in a blood sample of a patient with glucose-6-phosphate dehydrogenase deficiency? Why do they form?
Hb becomes cross-linked due to inappropriate disulphide bond formation - forms an insoluble aggregate called Heinz bodies
What are the differences between fibrous and globular proteins?
Fibrous - support, shape and protect. Long strands/sheets. Have a single type of repeating secondary structure.
Globular - involved in catalysis and regulation. Compact shape. Have several types of secondary structures