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CV PHARM...Functional Aspects of ANS > General > Flashcards

Flashcards in General Deck (86)
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1

What is the major disadvantage of clinical therapy involving drugs that act on ANS?

Lack of specificity

2

Parasympathetics control...

cardiac and smooth muscle
gland cells
nerve terminals

3

Parasympathetic presynaptic

nicotinic cholinergic

4

Parasympathetic postsynaptic

muscarinic cholinergic

5

Sympathetic (sweat glands) postsynaptic

muscarinic cholinergic

6

postsynaptic motor neurons

nicotinic cholinergic

7

sympathetic (cardiac and smooth muscle, gland cells, nerve terminals) postsynaptic motor neurons

adrenergic (alpha and beta)

8

Sympathetic (renal vascular smooth muscle) postsynaptic motor neuron

dopamine receptor

9

Adrenal medulla

nicotinic cholinergic receptor

releases Epi, NE

10

Cholinergic receptor types

muscarinic
Nicotinic

11

muscarinic subtypes

M1, M3, M5...Gq coupled

M2, M4....Gi coupled

12

Gq coupled muscarinic receptors

M1
M3
M5

13

Gi coupled muscarinic receptors

M2
M4

14

Nicotinic subtypes

Nm (neuromuscular/muscle type)
Nn (neuronal, or ganglion type)

15

Adrenergic subtypes

alpha 1, alpha 2
beta 1, beta 2, [beta 3]

16

Dopamine receptor subtypes

D1-D5

17

Other receptors

for NANC transmitters
--NO
--vasoactive intestinal peptide
--neuropeptide Y

18

5 key features of neurotransmitter function that provide targets for drug therapy?

Synthesis
Storage
Release
Reuptake
Degredation

19

If Synthesis and Storage blocked...

usually rate-limiting steps, so...
produce long-term effects, but not immediately effective

20

If release blocked...

Rapid action and effective

21

If reuptake blocked...

Increased synaptic neurotransmitter concentrations (selective or non-selective)

22

If metabolism blocked...

reversible or irreversible:
increases transmitter levels

23

If recognition is blocked...

Receptor antagonists and agonists...high specificity

24

Sympathomimetic

mimicks... effects of impulses conveyed by adrenergic postganglionic fibers

25

Sympatholytic

anti adrenergic...

26

Fundamental difference b/w methods of inactivation of acetylcholine vs. norepinephrine

acetylcholine-->degraded
NE-->reuptake

27

hemicholiniums

EXPERIMENTAL, NOT CLINICAL

block CHT (that transports Na and choline in)

28

Vesamicol

EXPERIMENTAL,, NOT CLINICAL

blocks VAT

29

Cotransmitters

modulation (enhance or diminish cholinergic activity)

30

Cholinergic Autoreceptors

ACh activates the receptors, but this inhibits further release of ACh